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FLASH GENE
Symbol NKRF contributors: mct/npt - updated : 30-10-2017
HGNC name NFKB repressing factor
HGNC id 19374
Location Xq24      Physical location : 118.722.301 - 118.739.846
Synonym name
  • transcription factor nrf
  • open reading frame from clone ITBA4
  • NF-kappaB repressing factor
  • Synonym symbol(s) ITBA4, NRF
    DNA
    TYPE functioning gene
    STRUCTURE 18.13 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3263 77 690 - 2017 28115624
    4 - 3361 - 705 - 2017 28115624
    2 - 3747 - 690 - 2017 28115624
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a G-patch
  • glycine-rich nucleic binding domain
  • an R3H domain at its C-terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text highly enriched in nucleoli and only a small fraction is found in the nucleoplasm and cytoplasm
    basic FUNCTION
  • required for transcriptional activation of the HIV-1 LTR in stimulated cells
  • interrupts the regulatory coupling of LTR binding factors and transcription elongation events (this inhibitory mechanism might contribute to transcriptional quiescence of integrated HIV-1 provirus)
  • plays a central role in mediating pathogen and cytokine-stimulated gene transcription
  • can silence the IFNbeta promoter
  • inhibits chemokine synthesis by peripheral blood mononuclear cells and alveolar macrophages in active pulmonary tuberculosis
  • NKRF is a novel RELB-response gene, and Neutrophil elastase (NE) is a stimulator of the non-canonical RELB/NFKB1 pathway in airway smooth muscle cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with specific negative regulatory DNA elements (NRE) to mediate transcriptional repression by inhibition of the NF-kappaB activity at certain promoters
  • negative regulatory mechanism of neutrophil elastase-induced NKRF, which is restricted to Airway smooth muscle (ASM) and mediates the suppression of IL8/CXCL8 expression
  • inhibits transcription elongation by binding to specific sequences in target promoters
  • NKRF mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis
  • cell & other
    REGULATION
    Other NKRF phosphorylation modulates promoter-proximal transcription elongation of NFKB1/NKRF-regulated genes via direct interactions with elongation complex in response to specific stimuli
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS