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FLASH GENE
Symbol NKIRAS2 contributors: - updated : 13-07-2005
HGNC name NFKB inhibitor interacting Ras-like 2
HGNC id 17898
Location 17q21.2      Physical location : 40.169.593 - 40.177.654
Synonym name
  • kappaB-Ras2
  • Synonym symbol(s) KBRAS2, MGC74742, DKFZP434N1526
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2968 21 191 - -
    - - 2492 21 191 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  predominantly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
     female systemovary  moderately
     male systemprostate  moderately
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Nkiras2
    intraspecies paralog to NKIRAS2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in small GTPase mediated signal transduction
  • GTPase
  • decreasing the rate of degradation of I-kappa-B-alpha and I-kappa-B-beta
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • I-kappaB kinase/NF-kappaB cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • PEST domains of I-kappa-B-alpha (NFKBIA)
  • PEST domains of I-kappa-B-beta (NFKBIB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS