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FLASH GENE
Symbol NKIRAS1 contributors: - updated : 13-07-2005
HGNC name NFKB inhibitor interacting Ras-like 1
HGNC id 17899
Location 3p24.2      Physical location : 23.933.573 - 23.958.537
Synonym name
  • kappaB-Ras1
  • I-kappa-B-interacting Ras-like protein 1
  • Synonym symbol(s) KBRAS1
    DNA
    TYPE functioning gene
    STRUCTURE 24.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
     male systemtestis  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Nkiras1
    intraspecies paralog to NKIRAS2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in small GTPase mediated signal transduction
  • GTPase
  • decreasing the rate of degradation of I-kappa-B-alpha and I-kappa-B-beta
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • I-kappaB kinase/NF-kappaB cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • PEST domains of I-kappa-B-alpha (NFKBIA)
  • PEST domains of I-kappa-B-beta (NFKBIB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS