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FLASH GENE
Symbol NKD2 contributors: mct/npt - updated : 10-02-2010
HGNC name naked cuticle homolog 2 (Drosophila)
HGNC id 17046
Location 5p15.33      Physical location : 1.009.167 - 1.038.925
Synonym name
  • Dvl-binding protein NKD2
  • naked cuticle-2
  • Synonym symbol(s) Naked2
    DNA
    TYPE functioning gene
    STRUCTURE 29.76 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1798 - 451 - Ding (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbraindiencephalonhypothalamus  
    Reproductivefemale systembreastmammary gland  
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Connectivebone   
    Epithelialsensoryvisual  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney, lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal half behaves as an intrinsically unstructured protein (Hu 2006)
  • one EF-hand motif
  • HOMOLOGY
    interspecies ortholog to murine Nkd2
    Homologene
    FAMILY
  • Naked family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inducible antagonists of canonical Wnt signaling (Ding 2008)
  • short-lived protein with a half-life of 60 min caused by its rapid ubiquitin-mediated proteasomal degradation (Ding 2008)
  • acting as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGFA-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells (Li 2007)
  • negatively regulates canonical Wnt signaling by binding Dishevelled (Li 2004)
  • having unexpected function, myristoylation-dependent escort of TGFA to the basolateral plasma membrane of polarized epithelial cells (Li 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacts with the cytoplasmic tail of TGFA, thereby coating TGFA-containing exocytic vesicles and directing these vesicles to the basolateral corner of polarized epithelial cells (Ding 2008)
  • interacts with TGFA and escorts TGFA-containing vesicles to the basolateral membrane of polarized epithelial cells (Hu 2006)
  • binds to basolateral sorting motifs in the cytoplasmic tail of TGFA (Li 2004)
  • myristoylated NKD2 interacts with DVL1 at the plasma membrane and this interaction leads to their mutual ubiquitin-mediated rpoteasomal degradation and thus antagonizes Wnt-beta-catenin activity (Hu 2010)
  • cell & other
    REGULATION
    Other stabilized by overexpression of TGFA in an EGF receptor (EGFR)-independent manner (Ding 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric, esophageal, pancreatic cancer
    tumoral   amplification --over  
    in soft tissue sarcomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS