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FLASH GENE
Symbol NKD1 contributors: mct/npt - updated : 08-02-2018
HGNC name naked cuticle homolog 1 (Drosophila)
HGNC id 17045
Location 16q12.1      Physical location : 50.582.240 - 50.668.641
Synonym name
  • Dvl-binding protein
  • naked cuticle-1
  • Synonym symbol(s) NKD, Naked1
    DNA
    TYPE functioning gene
    STRUCTURE 100.92 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ABCC11 16q11-q12 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 LONP 16q12.1 peroxisomal lon protease SIAH1 16q12 seven in absentia homolog 1 (Drosophila) LOC255896 16q12.1 similar to molybdenum cofactor synthesis-step 1 protein isoform 2 FLJ31821 16q12.1 hypothetical protein FLJ31821 N4BP1 16q12.1 hypothetical protein FLJ31821 LOC388273 16 LOC388273 CBLN1 16q11.2-q12.2 cerebellin 1 precursor MGC33367 16q12.1 hypothetical protein MGC32905 OAZ 16q12 hypothetical protein MGC32905 ADAM3B 16q12.1 a disintegrin and metalloproteinase domain 3b (cyritestin 2) MRPS21P7 16q12.1 mitochondrial ribosomal protein S21 pseudogene 7 MRPS21P8 16q12.1 mitochondrial ribosomal protein S21 pseudogene 8 FLJ38101 16q12.1 hypothetical protein FLJ38101 FLJ20718 16q12.1 hypothetical protein FLJ20718 LOC390729 16 similar to 60S ribosomal protein L10 (QM protein homolog) TRF4-2 16q12.1 topoisomerase-related function protein 4-2 ADCY7 16q12-q13 adenylate cyclase 7 BRD7 16q12 bromodomain containing 7 NKD1 16q12 naked cuticle homolog 1 (Drosophila) SLIC1 16q12.1 selectin ligand interactor cytoplasmic-1 CARD15 16q12 caspase recruitment domain family, member 15 LOC388274 16 LOC388274 CYLD 16q12-q13 cylindromatosis (turban tumor syndrome) SALL1 16q12.1 sal-like 1 (Drosophila) UNGP1 16q12.1 uracil-DNA glycosylase pseudogene 1 LOC388275 16 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC388276 16 LOC388276 LOC388277 16 LOC388277 TNRC9 16q12.2 trinucleotide repeat containing 9 LOC146253 16q12.2 tropomyosin-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 8716 52.15 470 - 2005 15687260
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH2 domain
  • one EF-hand binding motif
  • HOMOLOGY
    interspecies homolog to murine Nkd1
    intraspecies homolog to NKD2
    Homologene
    FAMILY
  • cuticular collagen family
  • NKD family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducible antagonists of canonical Wnt signaling (Ding 2008)
  • negatively regulates canonical Wnt signaling by binding Dishevelled (Li 2004)
  • functions as a passive antagonist of WNT signaling, functioning only when homeostatic levels of WNT signaling have been breached or when WNT signaling becomes destabilized
  • negative regulator of the Wnt signaling pathway, that is abnormally expressed in many types of malignant tumors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT-induced intracellular negative regulator of canonical WNT signaling
  • NKD1 binds to CTNNB1 and prevents its nuclear accumulation
  • NKD1 is recruited to the WNT signalosome with DVL2, where it becomes activated to move into the cytoplasm to interact with CTNNB1, inhibiting its nuclear accumulation
  • FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1
  • NKD1 repressed hepatocellular carcinoma (HCC) cell proliferation by inducing TP53 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia
    tumoral     --low  
    in hepatocellular carcinoma (HCC) tissues and correlated with a poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS