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FLASH GENE
Symbol NKD1 contributors: mct/npt - updated : 08-02-2018
HGNC name naked cuticle homolog 1 (Drosophila)
HGNC id 17045
Location 16q12.1      Physical location : 50.582.240 - 50.668.641
Synonym name
  • Dvl-binding protein
  • naked cuticle-1
  • Synonym symbol(s) NKD, Naked1
    DNA
    TYPE functioning gene
    STRUCTURE 100.92 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 8716 52.15 470 - 2005 15687260
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH2 domain
  • one EF-hand binding motif
  • HOMOLOGY
    interspecies homolog to murine Nkd1
    intraspecies homolog to NKD2
    Homologene
    FAMILY
  • cuticular collagen family
  • NKD family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducible antagonists of canonical Wnt signaling (Ding 2008)
  • negatively regulates canonical Wnt signaling by binding Dishevelled (Li 2004)
  • functions as a passive antagonist of WNT signaling, functioning only when homeostatic levels of WNT signaling have been breached or when WNT signaling becomes destabilized
  • negative regulator of the Wnt signaling pathway, that is abnormally expressed in many types of malignant tumors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT-induced intracellular negative regulator of canonical WNT signaling
  • NKD1 binds to CTNNB1 and prevents its nuclear accumulation
  • NKD1 is recruited to the WNT signalosome with DVL2, where it becomes activated to move into the cytoplasm to interact with CTNNB1, inhibiting its nuclear accumulation
  • FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1
  • NKD1 repressed hepatocellular carcinoma (HCC) cell proliferation by inducing TP53 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia
    tumoral     --low  
    in hepatocellular carcinoma (HCC) tissues and correlated with a poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS