basic FUNCTION
| playing a role in sister chromatid cohesion and developmental regulation |
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multi-functional protein with roles in chromosome function, gene regulation and double-strand DNA repair |
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required for the loading of Cohesin onto chromatin, have been implicated in double-strand DNA repair and in the regulation of gene expression (Jahnke 2008) |
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has a function in modulating chromatin architecture, particularly for gene-rich areas of the chromosome |
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plays an important role in chromatin compaction, having the most impact in regions of the genome with the highest gene density and the highest density of CTCF and cohesin binding sites |
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NIPBL and cohesin have been reported to affect long-range chromosomal interactions, both independently and through interactions with CTCF |
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a conserved patch on the surface of MAU2 is required to recruit NIPBL/MAU2 to centromeres and to build pericentromeric cohesion |
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balanced activity of NIPBL/MAU2 and WAPL enables cohesin to correctly structure chromosomes |
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NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes codify for the "cohesin complex" playing a role in chromatid adhesion, DNA repair and gene expression regulation |
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