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FLASH GENE
Symbol NID2 contributors: mct/npt - updated : 15/11/2008
HGNC name nidogen 2 (osteonidogen)
HGNC id 13389
Location 14q22.1      Physical location : 52.471.520 - 52.535.946
Synonym name nidogen 2
DNA
TYPE functioning gene
STRUCTURE 64.42 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ATP5S 14q21.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) CDKL1 14q22.1 cyclin-dependent kinase-like 1 (CDC2-related kinase) MAP4K5 14q13.2-q21 mitogen-activated protein kinase kinase kinase kinase 5 SPG3A 14q21.3 spastic paraplegia 3A (autosomal dominant) SNRPGP 14 small nuclear ribonucleoprotein polypeptide G pseudogene SAV1 14q13-q23 salvador homolog 1 (Drosophila) ZNF405P 14 zinc finger protein 405 pseudogene NIN 14q21.3-q22 ninein (GSK3B interacting protein) C14orf29 14q21.3 chromosome 14 open reading frame 29 PYGL 14q21.2 phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) MRP63P9 14q22.1 mitochondrial ribosomal protein 63 pseudogene 9 TRIM9 14q21.3 tripartite motif-containing 9 TXNDC 14q21.3 thioredoxin domain containing LOC283553 14q22.1 hypothetical LOC283553 SETP2 14 SET pseudogene 2 C14orf31 14q21.3 chromosome 14 open reading frame 31 LOC341856 14q22.1 similar to putative taste receptor HTR2 C14orf166 14q22.1 chromosome 14 open reading frame 166 NID2 14q21-q22 nidogen 2 (osteonidogen) COX5AP2 14 cytochrome c oxidase subunit Va pseudogene 2 PTGDR 14q22.1 prostaglandin D2 receptor (DP) PTGER2 14q21.2 prostaglandin E receptor 2 (subtype EP2), 53kDa KIAA1344 14q22.1 KIAA1344 DKFZp762F0713 14q22.1 hypothetical protein DKFZp762F0713 ERO1L 14q22.1 ERO1-like (S. cerevisiae) PSMC6 12q15 proteasome (prosome, macropain) 26S subunit, ATPase, 6 STYX  serine/threonine/tyrosine interacting protein GNPNAT1 14q22.1 glucosamine-phosphate N-acetyltransferase 1 PLEKHC1 14q22.1 pleckstrin homology domain containing, family C (with FERM domain) member 1 NDUFB3P3 14q22.3-q23.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 3 DDHD1 14q21 DDHD domain containing 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 5563 - 1375 - Miosge (2002)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Hearing/Equilibriumear   predominantly
Nervousspinal cord   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Epithelialsecretoryglandularendocrinehighly
Epithelialsecretoryglandularexocrine 
Membrane    
Muscularstriatumskeletal highly
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta, basement membrane in epithelia ans most organs
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five EGF like domains
  • two thyroglobulin type-1 domains
  • five LDL-receptor YWTD domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Nid2
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix
    basic FUNCTION
  • regulating interactions between adhesion receptors and the cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacting with perlecan, laminin A1, nidogen 1
  • collagens binding (I, IV, XIII)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    lack of nidogen-1 and -2 results in a specific and time-limited failure in the ectodermal basement membrane of the limb bud, causing dysregulation of interdigital apoptosis and syndactyly