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FLASH GENE
Symbol NGFRAP1 contributors: mct/npt - updated : 20-03-2018
HGNC name nerve growth factor receptor (TNFRSF16) associated protein 1
HGNC id 13388
Location Xq22.2      Physical location : 102.631.267 - 102.632.999
Synonym name
  • p75NTR-associated cell death executor
  • ovarian granulosa cell protein (13kD)
  • brain expressed, X-linked 3
  • Synonym symbol(s) HGR74, Bex3, NADE, DXS6984E
    DNA
    TYPE functioning gene
    STRUCTURE 1.73 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 980 - 111 - Alvarez (2005)
    isoform b
    3 - 933 - 101 - Alvarez (2005)
    isoform a
    1 - 891 - 111 - Alvarez (2005)
    isoform b
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
     male systemprostate   
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegranulosa cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • BEX family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be involved in p75NTR-mediated apoptosis induced by NGF
  • may play an important role in the pathogenesis of neurogenetic diseases
  • with BEX1 interact with NGFR and modulate nerve growth factor (NGF) signaling through nuclear factor-kappaB (NF-kappaB) to regulate cell cycle, apoptosis, and differentiation in neural tissues (Naderi 2007)
  • while BEX1 and NGFRAP1 act as tumor suppressors, BEX2 seems to act as an oncogene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the DEATH domain of NGFR
  • interactor for TSC1 (constitutively associated with NGFRAP1 to prevent its proteasomal degradation, to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in TSC) (Yasui 2007)
  • interact with VTA1, and the interaction occurred in cytoplasm (through N-terminus of VTA1 and the C-terminus of NGFRAP1 (Yu 2007)
  • interacts with the death domain of NGFR and mediates apoptosis in neural cells in response to nerve growth factor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS