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FLASH GENE
Symbol NFYC contributors: mct/npt - updated : 15-09-2012
HGNC name nuclear transcription factor Y, gamma
HGNC id 7806
Location 1p34.2      Physical location : 41.157.241 - 41.237.273
Synonym name
  • transactivator HSM1
  • CCAAT -binding transcription factor gamma subunit, binding the histone H1
  • nuclear transcription factor Y subunit C
  • Synonym symbol(s) CBFC, H1TF2A, HAP5, HSM1, CBF-C, CBFC, FLJ45775, HSM, NF-YC, DKFZp667G242
    DNA
    TYPE functioning gene
    STRUCTURE 80.03 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HPCAL4 1p34.2 hippocalcin like 4 PPIE 1p32 peptidylprolyl isomerase E (cyclophilin E) BMP8B 1p35-p32 bone morphogenetic protein 8 b(osteogenic protein 2) OXCT2 1p34 3-oxoacid CoA transferase 2 IPT 1p35.3-p34.1 3-oxoacid CoA transferase 2 MYCL1 1p34.2 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) FLJ14490 1p34.2 hypothetical protein FLJ14490 CAP1 1p34.2 CAP, adenylate cyclase-associated protein 1 (yeast) PPT1 1p32 palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) RLF 1p32 rearranged L-myc fusion sequence LOC127391 1p34.2 similar to dJ39G22.2 (novel protein) ZMPSTE24 1p34.1-p33 zinc metalloproteinase (STE24 homolog, yeast) COL9A2 1p33-p32.3 collagen, type IX, alpha 2 LOC388621 1 similar to 60S ribosomal protein L21 LOC391028 1 similar to Csa-19 LOC64744 1p35.3-p34.1 hypothetical protein AL133206 LOC65243 1p34.2 hypothetical protein LOC65243 FLJ16030 1p34.2 FLJ16030 protein FLJ21144 1p34.2 hypothetical protein FLJ21144 MGC27466 1p34.2 hypothetical protein MGC27466 LOC391029 1 similar to General transcription factor IIF, polypeptide 2 RIMS3 1pter-p22.2 regulating synaptic membrane exocytosis 3 NFYC 1p32 nuclear transcription factor Y, gamma KCNQ4 1p34 potassium voltage-gated channel, KQT-like subfamily, member 4 CITED4 1p34.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 LOC388622 1 LOC388622 CTPS 1p34.1 CTP synthase FLJ23878 1p34.1 hypothetical protein FLJ23878 SCMH1 1p34 sex comb on midleg homolog 1 (Drosophila) LOC388623 1 LOC388623 LOC391030 1 similar to forkhead box protein O6 EDN2 1p34.1 endothelin 2 HIVEP3 1p34 human immunodeficiency virus type I enhancer binding protein 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2162 - 354 - 2009 19690168
    10 - 2105 37.2 335 - 2009 19690168
  • HSM2
  • specific role of the 37-kDa isoform in suppression of the DNA damage-response under growing conditions
  • the 37- and 50-kDa isoforms are mutually exclusive
  • - - 2160 50.3 458 - 2009 19690168
  • the 37- and 50-kDa isoforms are mutually exclusive
  • 10 - 2102 - 334 - 2009 19690168
    9 - 1991 - 297 - 2009 19690168
    15 - 2380 - 301 - 2009 19690168
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Lymphoid/Immunespleen   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to rattus Cbfc
    intraspecies homolog to H2B
    Homologene
    FAMILY
  • NFYC/HAP5 subunit family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • contributing to cell-cycle dependent regulation of HSP70
  • functions as a new corepressor of agonist-bound NR3C2 via alteration of aldosterone-induced NR3C2 conformation
  • SP1, NFYC and FOXO3, FOXO4 transcription factors are involved in the regulation of STK11 transcription
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    protein
    PHYSIOLOGICAL PROCESS
    text cell-cycle control
    PATHWAY
    metabolism
    signaling
    a component
  • forming a trimeric complex with NFYA and NFYB
  • heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC, which specifically binds the CCAAT consensus present in about 30p100 of eukaryotic promoters
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the CCAAT and the inverted CCAT box, Y box (ATGG) motifs in a variety of promoters
  • binding MYC on the G1-specific enhancers of HSP70
  • interacting with SARS2 (NFYA, NFYB, NFYC influences directionality of transcription from the bidirectional MRPS12/SARS2 promoter)
  • NFYC transcription factor is the CCAAT activator controlling transactivation of the CFDP1 promoter
  • NFYA, NFYB, NFYC, cooperates with FOXO3 to recruit EP300 to the BCL2L11 promoter to form a stable multi-protein/DNA complex that activates BCL2L11 transcription after survival factor withdrawal
  • NFYA, NFYB, NFYC can act as a transcriptional activator of ABCB4
  • cell & other
    REGULATION
    activated by ATF6
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS