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FLASH GENE
Symbol NFYA contributors: mct - updated : 12-12-2012
HGNC name nuclear transcription factor Y, alpha
HGNC id 7804
Location 6p21.1      Physical location : 41.040.706 - 41.070.145
Genatlas name CCAAT-binding transactivation factor, alpha subunit
Synonym name
  • CAAT-box DNA binding protein subunit A
  • CCAAT-binding transcription factor subunit B
  • HAP2 CCAAT-binding protein
  • Synonym symbol(s) CBFA, HAP2, CBF-A, CBF-B, NF-YA
    DNA
    TYPE functioning gene
    STRUCTURE 29.44 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC389388 6 LOC389388 KIAA1246 6p21.1 LOC389388 UNC5CL 6p21.1 unc-5 homolog C (C. elegans)-like BZRPL1 6p21.1 benzodiazapine receptor (peripheral)-like 1 APOBEC2 6p21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 C6orf130 6p21.1 chromosome 6 open reading frame 130 NFYA 6p21.3 nuclear transcription factor Y, alpha LOC221442 6p21.1 hypothetical protein LOC221442 TREML1 6p21.1 triggering receptor expressed on myeloid cells-like 1 TREM2 6p21.1 triggering receptor expressed on myeloid cells 2 C6orf76 6p21.1 chromosome 6 open reading frame 76 LOC285852 6p21.1 hypothetical protein LOC285852 TREM1 6p21.1 triggering receptor expressed on myeloid cells 1 NCR2 6p21.1 natural cytotoxicity triggering receptor 2 FOXP4 6p21.1 forkhead box P4 MDFI 6p21 MyoD family inhibitor TFEB 6p21 transcription factor EB PGC 6p22-p12 progastricsin (pepsinogen C) FRS3 6p21.1 fibroblast growth factor receptor substrate 3 C6orf49 6p21.31 chromosome 6 open reading frame 49 MGC20741 6p21 ubiquitin specific protease 49
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6236 36.9 347 - 2012 22285817
    including exon b
    9 splicing 6149 33.8 318 - 2012 22285817
    lacking alternate exon b
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal A domain
  • a highly conserved central B domain involved in DNA binding
  • a C terminal C domain rich in glutamine and acidic residues involved in protein-protein interactions with various genes
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to yeast Hap3 subunit
    Homologene
    FAMILY cbf-a subfamily
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating the transcriptional regulation by recognizing the CCAAT motif in promoter
  • mediating the transcriptional regulation of MDR1 by histone acetyltransferase and deaminase
  • mediating the interaction of BRCA1 to GADD45 through its binding to CAAT motif of BRCA1
  • mediating ABCB1 regulation by PCAF
  • potent cellular regulator of hematopoietic stem cell (HSC) self-renewal
  • pivotal upstream participant in a regulatory network necessary for the preservation of cycling hematopoietic stem cell
  • role in the regulation of human proteasome genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a trimeric complex with NFYB and NFYC
  • CDKN1A/NFYA/PLK1 axis critical for maintaining the checkpoint function of TP53 to prevent mitotic death in the DNA damage-induced response
  • INTERACTION
    DNA binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in HLA genes and a variety of promoters
    RNA
    small molecule
    protein
  • binding to NFYB, NFYC
  • functions as a key regulator of SOX3 gene expression
  • interacting with mutant HTT
  • interacting with SARS2 (NFYA, NFYB, NFYC influences directionality of transcription from the bidirectional MRPS12/SARS2 promoter)
  • NFYA, NFYB, NFYC, cooperates with FOXO3 to recruit EP300 to the BCL2L11 promoter to form a stable multi-protein/DNA complex that activates BCL2L11 transcription after survival factor withdrawal
  • CDK2/CCNA2 can phosphorylate and activate the transcription factor NFYA
  • TBP interacts with NFY subunit A (NFYA), which could be a target of mutant TBP in SCA17
  • NFYA, NFYB, NFYC can act as a transcriptional activator of ABCB4
  • cell & other
    REGULATION
    activated by ATF6
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    led to a delay in S-phase progression, DNA damage and apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential target for cancer therapy
    ANIMAL & CELL MODELS