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FLASH GENE
Symbol NFX1 contributors: mct/npt - updated : 10-06-2009
HGNC name nuclear transcription factor, X-box binding 1
HGNC id 7803
Location 9p13.3      Physical location : 33.290.417 - 33.371.154
Synonym name
  • transcriptional repressor NF-X1
  • human cysteine-rich sequence-specific DNA-binding protein NFX1 mRNA
  • Synonym symbol(s) MGC20369, NFX2, NF-X1, DKFZp779G2416
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 80.64 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392302 9 similar to argininosuccinate synthetase APTX 9p13.3 aprataxin DNAJA1 9p13-p12 DnaJ (Hsp40) homolog, subfamily A, member 1 SMU-1 9p12 homolog of C. elegans smu-1 B4GALT1 9p13 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 SPINK4 9p12 serine protease inhibitor, Kazal type 4 BAG1 9p12 BCL2-associated athanogene HSPC177 NFX1 9p12 nuclear transcription factor, X-box binding 1 AQP7 9p13 aquaporin 7 AQP3 9p13 aquaporin 3 NOL6 9p13.2 nucleolar protein family 6 (RNA-associated) bA255A11.3 9p12 FLJ35740 pseudogene LOC389711 9 similar to hypothetical protein DKFZp434F1719
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3200 - 833 - Katzenellenbogen (2007)
    24 - 4629 - 1120 - Katzenellenbogen (2007)
    16 - 3548 - 833 - Katzenellenbogen (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunethymus   highly
    Respiratoryrespiratory tracttrachea  highly
     respiratory tractlarynx  highly
    cell lineage
    cell lines all cell lines tested
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • R3H domain
  • NF-X1 type zinc finger motifs
  • zinc finger domain (Ring type)
  • central cystein rich DNA binding domain subdivised into seven repeated motifs
  • HOMOLOGY
    interspecies homolog to murine Nfx1
    homolog to C.elegans c16a3.7
    Homologene
    FAMILY
  • NFX1 family
  • CATEGORY enzyme , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in regulation of the duraton of an inflammatory response
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS inflammation
    text pol2 transcription
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • specific binding partner for ELAVL4
  • NFX1-91 interacts with the corepressor complex SIN3A/histone deacetylase (HDAC) at the TERT promoter, and repress TERT transcription in keratinocytes (Xu 2008)
  • cell & other
    REGULATION
    induced by interferon gamma (IFNG)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS