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FLASH GENE
Symbol NFKBIZ contributors: mct/npt/pgu - updated : 27-01-2015
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
HGNC id 29805
Location 3q12.3      Physical location : 101.546.833 - 101.579.868
Synonym name
  • likely ortholog of mouse I kappa B-zeta
  • molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse
  • IL-1 inducible nuclear ankyrin-repeat protein
  • I-kappa-B-zeta
  • Synonym symbol(s) IKBZ, INAP, MAIL, FLJ34463, FLJ30225, MAIL-S
    DNA
    TYPE functioning gene
    STRUCTURE 33.01 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3934 - 718 - 2006 16622025
    13 - 3801 68 618 - 2006 16622025
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     stomach   highly
    Lymphoid/Immunespleen    
    Nervousspinal cord    
    Reproductivefemale systemovary   
    Respiratorylung   highly
    Skin/Tegumentskin    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal of NFKBIZ important for nuclear localization
  • C-terminal 6 ankyrin repeats
  • HOMOLOGY
    interspecies homolog to murine Ikbz
    Homologene
    FAMILY
  • Bcl-3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized in the nucleus where it aggregates in matrix-associated deacetylase bodies
    basic FUNCTION
  • playing a role in activation of IL-6 production
  • absolutely required for expression of the pluripotent pro-inflammatory cytokine interleukin-6 in peritoneal macrophages (T
  • functions as an additional regulator of NF-kappaB activity and, hence, provides another control level for the activation of NF-kappaB-dependent target genes
  • essential for the activation of NK cells and antiviral host defense responses
  • required for the activation of NK cells in response to IL12B and IL18
  • plays an essential role in the activation of NK cells by triggering dynamic transcription factor recruitment and chromatin remodeling
  • functions as an important regulator of IFNG in human NK cells, further expanding the class of NFKBIZ-modulated genes
  • distinguished role of NFKBIZ in mediating the targeted recruitment of monocytes in response to local inflammatory events
  • critical roles for NFKBIZ in TLR signaling in B cells
  • essential role of NFKBIZ in regulating a specific set of NFKB1 target genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with both the p65 and p50 subunit of NF-kappaB and inhibits the transcriptional activity as well as the DNA binding of the transcription factor
  • interacting with FUS-DDIT3 (FUS-DDIT3-mediated nuclear transport of NFKBIZ)
  • NFKBIZ is directly recruited to the proximal promoter region of the CCL2 gene and is required for transcription-enhancing histone H3 at lysine-4 trimethylation
  • AKIRIN2 bridging NFKB1 and the chromatin remodeling SWI/SNF complex by interacting with SMARCD proteins as well as NFKBIZ, which forms a complex with the NFKB1 p50 subunit
  • regulates TLR-mediated class switch recombination (CSR) by inducing activation-induced cytidine deaminase (AID)
  • cell & other
    REGULATION
    induced by lipopolysaccharide
    in response to various Toll-like receptor (TLR)/IL1 receptor (IL1R) stimuli in macrophages
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS