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FLASH GENE
Symbol NFKBIE contributors: npt/ - updated : 04-01-2006
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
HGNC id 7799
Location 6p21.1      Physical location : 44.225.902 - 44.233.525
Synonym name
  • inhibitor of Kappa light chain enhancer in B cells, epsilon
  • I-kappa-B-epsilon
  • Synonym symbol(s) EVI132, IKBE, NF-kappa-BIE, IkB-epsilon
    DNA
    TYPE functioning gene
    STRUCTURE 7.62 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    POLH 6p21.1-p12 polymerase (DNA directed), eta GTPBP2 6p21-p12 GTP binding protein 2 MAD2L1BP 6p21.1 MAD2L1 binding protein C6orf206 6p21.1 chromosome 6 open reading frame 205 MRPS18A 6p21.3 mitochondrial ribosomal protein S18A VEGF 6p12 vascular endothelial growth factor LOC389392 6 LOC389392 MGC45491 6p21.1 hypothetical protein MGC45491 LOC391921 6 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) MRPL14 6p21.3 mitochondrial ribosomal protein L14 C6orf110 6p21.1 chromosome 6 open reading frame 110 CAPN11 6p12 calpain 11 LOC389393 6 LOC389393 SLC29A1 6p21.2-p21.1 solute carrier family 29 (nucleoside transporters), member 1 HSPCB 6p12 heat shock 90kDa protein 1, beta SLC35B2 6p12.1-p11.2 solute carrier family 35, member B2 NFKBIE 6p21.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon LOC391922 6 similar to hypothetical protein MGC33486 MGC33600 6p21.1 hypothetical protein MGC33600 AARSL 6p21.1 alanyl-tRNA synthetase like SPATS1 6p21.1 spermatogenesis associated, serine-rich 1 CDC5L 6p21 CDC5 cell division cycle 5-like (S. pombe) SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2581 52.7 500 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver    
    Endocrinepancreas   moderately
    Lymphoid/Immunespleen   highly
    Nervousbrain   moderately
    Reproductivemale systemtestis  highly
     male systemprostate   
    Respiratorylung   highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six ankyrin repeats
  • two conserved serines
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Nfkbie
    Homologene
    FAMILY
  • NF-Kappa B inhibitor family
  • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of NFKB that tightly regulates NFKB activation by complexing and trapping it the cytoplasm
  • inhibiting NFkappaB by preventing its translocation to the nucleus
  • CELLULAR PROCESS nucleotide, transcription
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to p52 subunit of RELA-CRel-NFKB complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS