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FLASH GENE
Symbol NFKBIB contributors: mct - updated : 12-01-2011
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
HGNC id 7798
Location 19q13.2      Physical location : 39.390.614 - 39.399.533
Synonym name
  • thyroid hormone receptor interactor 9
  • IkappaB beta
  • TR-interacting protein 9
  • NF-kappa-B inhibitor beta
  • Synonym symbol(s) IKBB, IKBIB, TRIP9, NF-kappa-BIB
    DNA
    TYPE functioning gene
    STRUCTURE 8.92 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2213 - 306 - 2010 20740013
  • IkappaB beta
  • essential for the propagation of mitochondrial stress signaling
  • major isoform of IkappaB, can sequester NF-kappaB in the cytoplasm, although its biological role remains unclear
  • blocking IkappaBbeta might be a promising new strategy for selectively inhibiting the chronic phase of TNF-alpha production during the inflammatory response
  • 6 - 1198 35 356 - 2010 20740013
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines cervical carcinoma
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing male gonads
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six copies of the ankyrin repeat (ankyrin region)
  • a consensus sequence for PKC phosphorylation
  • a PEST sequence
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Nfkbib
    Homologene
    FAMILY
  • nf-kappa-b inhibitor family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • transcription factor of kappa light chain gene enhancer in B cells
  • distinctive physiological role for NFKBIB isoforms in the propagation of mitochondrial respiratory stress signaling
  • prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded
  • may be playing a role in spermatogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding to kappa-binding motif
    RNA
    small molecule
    protein
  • thyroid hormone receptor-beta
  • inhibitor kappa b-interacting ras-like protein 1
  • inhibitor kappa b-interacting protein ras 2
  • interacting with RELA (tight control of NFKBIB protein by RELA is necessary for the maintenance of cellular homeostasis)
  • target for transcription factors of the HMG-box SRY/Sox family
  • POLR2H
  • NKIRAS1
  • in dendritic cells (DCs), ARIH2 caused degradation of the inhibitor NFKBIB in the nucleus, which abrogated its ability to sequester, protect and transcriptionally coactivate the transcription factor subunit RELA in the nucleus
  • cell & other
    REGULATION
    Other regulated by RPS6KA1 (RPS6KA1 is a key component that directly phosphorylates NFKBIB and contributes to the persistent activation of NF-kappaB by IL1B)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGM2 polymerization
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target targeting NFKBIB might be a promising new strategy to treat chronic inflammatory diseases such as arthritis
    ANIMAL & CELL MODELS