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FLASH GENE
Symbol NFKBIB contributors: mct - updated : 12-01-2011
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
HGNC id 7798
Location 19q13.2      Physical location : 39.390.614 - 39.399.533
Synonym name
  • thyroid hormone receptor interactor 9
  • IkappaB beta
  • TR-interacting protein 9
  • NF-kappa-B inhibitor beta
    • Synonym symbol(s) IKBB, IKBIB, TRIP9, NF-kappa-BIB
    DNA
    TYPE functioning gene
    STRUCTURE 8.92 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PSMD8 19q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 GGN 19q13.13 gametogenetin LOC388538 19 similar to SPRED-3 LOC147965 19q13.2 hypothetical protein LOC147965 RASGRP4 19q13.1 RAS guanyl releasing protein 4 RYR1 19q13.1 ryanodine receptor 1 (skeletal) MAP4K1 19q13.2 mitogen-activated protein kinase kinase kinase kinase 1 eIF3k 19q13.2 mitogen-activated protein kinase kinase kinase kinase 1 ACTN4 19q13 actinin, alpha 4 CAPN12 19q13.2 calpain 12 LGALS7 19q13.2 lectin, galactoside-binding, soluble, 7 (galectin 7) LGALS4 19q13.2 lectin, galactoside-binding, soluble, 4 (galectin 4) ECH1 19q13.1 enoyl Coenzyme A hydratase 1, peroxisomal HNRPL 19q13.2 heterogeneous nuclear ribonucleoprotein L FLJ45909 19q13.2 FLJ45909 protein SIRT2 19q13 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) NFKBIB 19q13.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta LOC388539 19 LOC388539 SARS2 19q13.2 seryl-tRNA synthetase 2 MRPS12 19q13.11 mitochondrial ribosomal protein S12 FBXO26 19q13.2 F-box only protein 26 FBXO27 19q13.2 F-box only protein 27 LOC390928 19 similar to RIKEN cDNA C330005M16 LOC284321 19q13.2 hypothetical LOC284321 PAK4 19q13.2 p21(CDKN1A)-activated kinase 4 LOC342897 19q13.2 similar to F-box only protein 2 SYCN 19q13.2 syncollin IL28B 19q13.13 interleukin 28B (interferon, lambda 3) LOC390929 19 similar to Methionine-R-sulfoxide reductase (Selenoprotein X 1) (HSPC270)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2213 - 306 - 2010 20740013
  • IkappaB beta
  • essential for the propagation of mitochondrial stress signaling
  • major isoform of IkappaB, can sequester NF-kappaB in the cytoplasm, although its biological role remains unclear
  • blocking IkappaBbeta might be a promising new strategy for selectively inhibiting the chronic phase of TNF-alpha production during the inflammatory response
    • 6 - 1198 35 356 - 2010 20740013
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines cervical carcinoma
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing male gonads
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six copies of the ankyrin repeat (ankyrin region)
  • a consensus sequence for PKC phosphorylation
  • a PEST sequence
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Nfkbib
    Homologene
    FAMILY
  • nf-kappa-b inhibitor family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • transcription factor of kappa light chain gene enhancer in B cells
  • distinctive physiological role for NFKBIB isoforms in the propagation of mitochondrial respiratory stress signaling
  • prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded
  • may be playing a role in spermatogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding to kappa-binding motif
    RNA
    small molecule
    protein
  • thyroid hormone receptor-beta
  • inhibitor kappa b-interacting ras-like protein 1
  • inhibitor kappa b-interacting protein ras 2
  • interacting with RELA (tight control of NFKBIB protein by RELA is necessary for the maintenance of cellular homeostasis)
  • target for transcription factors of the HMG-box SRY/Sox family
  • POLR2H
  • NKIRAS1
    • cell & other
    REGULATION
    Other regulated by RPS6KA1 (RPS6KA1 is a key component that directly phosphorylates NFKBIB and contributes to the persistent activation of NF-kappaB by IL1B)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGM2 polymerization
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target targeting NFKBIB might be a promising new strategy to treat chronic inflammatory diseases such as arthritis
    ANIMAL & CELL MODELS