Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NFKBIB | contributors: mct - updated : 12-01-2011 |
HGNC name | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
HGNC id | 7798 |
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Location | 19q13.2 Physical location : 39.390.614 - 39.399.533 |
Synonym name | |
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Synonym symbol(s) | IKBB, IKBIB, TRIP9, NF-kappa-BIB |
DNA |
TYPE | functioning gene |
STRUCTURE | 8.92 kb 6 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| cervical carcinoma | fluid/secretion
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at STAGE |
physiological period | embryo |
Text | developing male gonads |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | PhosphoP |
HOMOLOGY |
interspecies | homolog to murine Nfkbib |
Homologene |
FAMILY |
CATEGORY | regulatory , transcription factor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, transcription, regulation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
a component |
INTERACTION |
DNA | binding to kappa-binding motif |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | regulated by RPS6KA1 (RPS6KA1 is a key component that directly phosphorylates NFKBIB and contributes to the persistent activation of NF-kappaB by IL1B) |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
| targeting NFKBIB might be a promising new strategy to treat chronic inflammatory diseases such as arthritis |
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ANIMAL & CELL MODELS |