basic FUNCTION
| survival of early B-cell progenitors |
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activating IL3 gene expression and repressing also transcription |
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negative regulator of the cyclooxygenase-2 (PTGS2) pathway that drives the expression of both RUNX2 and Osterix |
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osteoblast transcriptional repressor in inhibiting both RUNX2 and SP7 in myeloma bone disease (effect correlated with the increased PTHRP activity) |
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specific and essential requirement for the development of cells of the NK lineage |
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survival factor in pro-B lymphocytes |
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plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development |
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is potentially a critical regulator for IgE production and airway hyper-responsiveness |
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strongly suppresses FGF21 transcription by binding to a D-box element in the distal promoter region |
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novel insulin-responsive repressor of FGF21 expression during circadian cycles and feeding |
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important for maintaining a repressive state of the FGF21 gene during feeding and in response to insulin in hepatocytes |
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regulatory transcription factor in macrophages, controlling IL12B production induced by bacterial products and the enteric microbiota |
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plays an essential role in the development of CD8A(+) conventional dendritic cells |
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regulates cytokine production and effector function by T(H)2 cells |
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key regulator of T(H)2 responses |
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DBP and NFIL3 proteins are critical for determining the period length of the circadian oscillator |
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STAT3-dependent expression of NFIL3 is a key component of a negative feedback pathway in myeloid cells that suppresses proinflammatory responses |
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drives the formation of mature NK cells by inducing EOMES expression, revealing the differential requirements of NK cell subsets for NFIL3 |
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may contribute to the process of dexamethasone-induced osteoblast apoptosis |
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is a key regulator of the development of Innate lymphoid cell (ILC) subsets essential for immune protection in the lung and gut |
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plays a critical role in the development of other mucosal tissue-associated innate lymphocytes |
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is crucial for development of innate lymphoid cells and host protection against intestinal pathogens |
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is an important negative transcription factor, which through binding to the promoter of IGF2R, suppresses the apoptosis induced by IGF2R signaling in cardiomyoblast cells under hypoxic conditions |
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circadian protein indispensable for NK cell development |
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is a critical regulator of the common helper-like innate lymphoid cell progenitor (CHILP) |
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is a key regulator of common helper-like innate lymphoid cells (ILCs) progenitors as they emerge during early lymphopoiesis |
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when NFIL3 function was inhibited specifically in dorsal root ganglia prior to sciatic nerve injury, decrease in regenerative axon growth into the distal nerve segment rather than an increase |
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