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FLASH GENE
Symbol NFE2L3 contributors: mct - updated : 05-03-2011
HGNC name nuclear factor (erythroid-derived 2)-like 3
HGNC id 7783
Location 7p15.2      Physical location : 26.191.846 - 26.226.754
Synonym name NF-E2-related factor 3
Synonym symbol(s) NRF3
DNA
TYPE like-sequence
STRUCTURE 34.91 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3720 - 694 - 2005 15388789
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately Homo sapiens
Reproductivefemale systemplacenta  predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text pregnancy, highly, in primary placental cytotrophoblasts, but not in placental fibroblasts
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal domain with an NHB1 (N-terminal homology
  • box 1; AAs 1130) and an NHB2 (N-terminal
    homology box 2; AAs 82106), required for its activity as it contributes to the sorting of the factor within the ER
  • a basic leucine zipper (bZIP) domain
  • HOMOLOGY
    Homologene
    FAMILY Cap'n'collar (CNC) family of transcription factor
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence
    basic FUNCTION
  • activates erythroid-specific, globin gene expression
  • potent transcriptional activator, having a possible role in placental gene expression and development
  • N-glycosylated protein associated with the endoplasmic reticulum
  • involved in reactive oxygen species balancing and in muscle precursor migration during early embryo development
  • involved in the endoplasmic reticulum stressor induced SMC differentiation
  • has a crucial role in smooth muscle cell differentiation from stem cells and could be a potential target for manipulation of stem cell differentiation toward vascular lineage
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the DNA-antioxidant responsive elements (ARE)
  • cell & other
    REGULATION
    activated by the ER stressors tunicamycin and brefeldin A, and NHB1 is required for this response
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in choriocarcinoma cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS