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FLASH GENE

Symbol

NFE2L3

contributors: mct - updated : 05-03-2011

HGNC name	nuclear factor (erythroid-derived 2)-like 3
HGNC id	7783

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p15.2      Physical location : 26.191.846 - 26.226.754
Synonym name	NF-E2-related factor 3
Synonym symbol(s)	NRF3

DNA

TYPE	like-sequence
STRUCTURE	34.91 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004289 4 - 3720 - 694 - 2005 15388789

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately Homo sapiens Reproductive female system placenta     predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	pregnancy, highly, in primary placental cytotrophoblasts, but not in placental fibroblasts

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal domain with an NHB1 (N-terminal homology
	box 1; AAs 11–30) and an NHB2 (N-terminal
	homology box 2; AAs 82–106), required for its activity as it contributes to the sorting of the factor within the ER
	a basic leucine zipper (bZIP) domain

HOMOLOGY

Homologene

FAMILY

Cap'n'collar (CNC) family of transcription factor

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
text	membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence

basic FUNCTION	activates erythroid-specific, globin gene expression
	potent transcriptional activator, having a possible role in placental gene expression and development
	N-glycosylated protein associated with the endoplasmic reticulum
	involved in reactive oxygen species balancing and in muscle precursor migration during early embryo development
	involved in the endoplasmic reticulum stressor induced SMC differentiation
	has a crucial role in smooth muscle cell differentiation from stem cells and could be a potential target for manipulation of stem cell differentiation toward vascular lineage

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE)

INTERACTION

DNA

RNA

small molecule

protein

bind to the DNA-antioxidant responsive elements (ARE)

cell & other

REGULATION

activated by

the ER stressors tunicamycin and brefeldin A, and NHB1 is required for this response

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in choriocarcinoma cell lines

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS