activated T-cell (NFAT) family of transcription factors
CATEGORY
transcription factor
SUBCELLULAR LOCALIZATION
intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
text
cytoplasmic phosphorylated form
nuclear after activation controlled by calcineurin-mediated dephosphorylation
undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min depolarization
basic FUNCTION
acting as a putative regulator of gene expression in T cells and immature thymocytes and of cytokines to suppress local aberrant growth of vessels
inducing chondrogenesis and chondrocyte gene expression
required for cardiac development and mitochondrial function
calcineurin/NFATC3 signaling pathway regulates the expression of the 1 subunit of Ca2+-activated K+ (BK) channel in arterial smooth muscle and plays a critical role in the development of angiotensin II-induced hypertension
translocates to the nucleus in response both to a slow and to a fast-like pattern of activity (Calabria 2009)
transcriptionally active in fast muscles, i.e., in response to less frequent calcium transients and, presumably, lower Calcineurin activity (Calabria 2009)
transcription factor tightly regulated by the calcium/calmodulin-dependent phosphatase, calcineurin, activated in astrocytes applied with calcium ionophore or APP (
positive feedback control between STIM1/SOCE and NFATC3 is required for efficient induction and progression of myoblast differentiation
NFATC2, NFATC3 possess distinct nuclear localization dynamics in response to cell stimulation
important and novel regulatory mechanisms of NFATC3 activation in in pulmonary arterial smooth muscle cells (PASMC) by ROS
transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells (pDCs)
RhoA/Rho kinase (ROK) increases actin polymerization, thus providing structural support for NFATC3 nuclear transport
GPC6 is a novel NFATC1, NFATC2, NFATC3, NFATC4 target gene in breast cancer cells that promotes invasive migration through WNT5A signalling
NFATC3 promotes BACE1 expression via direct interaction with the BACE1 promoter
STIM1 regulates NFATC3 expression and its activity, and myotube formation
regulates the expression levels of STIM1 and ORAI1, and the activity of SOCE in C2C12 myoblasts
astrocyte MMP3 expression was induced by overexpression of a constitutively active form of NFATC3
TRIM17 binds preferentially SUMOylated forms of NFATC3
NFATC3 binds to the promoter of the TRIM17 gene together with JUN
NR4A1 functionally interacts with NFATC3 and GATA4 and inhibits their transcriptional activities, which are critical for the development of cardiac hypertrophy
NFATC3 specifically binds to IRF7 and enhances IRF7-mediated IFN production
cell & other
REGULATION
activated by
calcineurin
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
constitutional
 
 
 
gain of function
transiently up-regulated in the early phase of myoblast differentiation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
is a marker of activation for a specific population of astrocytes in response to brain damage, which may have consequences for neuronal survival