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FLASH GENE
Symbol NEUROD6 contributors: shn - updated : 11-05-2012
HGNC name neuronal differentiation 6
HGNC id 13804
Location 7p14.3      Physical location : 31.377.081 - 31.380.538
Synonym name
  • neurogenic differentiation 6
  • neurogenic differentiation factor 6
  • class A basic helix-loop-helix protein 2
  • protein atonal homolog 2
  • Synonym symbol(s) Atoh2, bHLHa2, Math-2, Nex1, NEX1M, My051, MATH2
    DNA
    TYPE functioning gene
    STRUCTURE 3.46 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D7S632 - D7S526 - NEUROD6 - D7S474 - D7S3045 - cen
    Physical map
    LOC392791 7 LOC392791 LOC392792 7 hypothetical gene supported by AK125651; BC039420 GARS 7p15 glycyl-tRNA synthetase LOC223082 7p15.1 zinc finger/RING finger 2 CRHR2 7p21-p15 corticotropin releasing hormone receptor 2 DKFZp586I1420 7p15.1 hypothetical protein DKFZp586I1420 INMT 7p15.3-p15.2 indolethylamine N-methyltransferase LOC392651 7 similar to hypothetical protein FLJ22374 CARD4 7p15-p14 caspase recruitment domain family, member 4 C7orf24 7p15-p14 chromosome 7 open reading frame 24 LOC392987 7 similar to ribosomal protein L27 AQP1 7p14 aquaporin 1 (channel-forming integral protein, 28kDa) GARS 7p15 glycyl-tRNA synthetase MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs GHRHR 7p14 growth hormone releasing hormone receptor CRHR2 7p21-p15 corticotropin releasing hormone receptor 2 ADCYAP1R1 7p14 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I INMT 7p15.3-p15.2 indolethylamine N-methyltransferase FLJ22374 7p15.1 hypothetical protein FLJ22374 PODXL 7q32-q33 podocalyxin-like AQP1 7p14 aquaporin 1 (channel-forming integral protein, 28kDa) LOC392793 7 similar to eukaryotic translation elongation factor 1 beta 2; eukaryotic translation elongation factor 1 beta 1 LOC392988 7 similar to ribosomal protein S14 GHRHR 7p14 growth hormone releasing hormone receptor NEUROD6 7p15.3 neurogenic differentiation 6 ADCYAP1R1 7p14 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I LOC223075 7p15.1 hypothetical protein LOC223075 NEUROD6 7p15.3 neurogenic differentiation 6 C7orf16 7p15 chromosome 7 open reading frame 16 PLXNA4 7q32.3 plexin A4 PDE1C 7p15.3 phosphodiesterase 1C, calmodulin-dependent 70kDa LOC223075 7p15.1 hypothetical protein LOC223075 C7orf16 7p15 chromosome 7 open reading frame 16 DKFZp434G0625 7q32.3 hypothetical protein DKFZp434G0625 PDE1C 7p15.3 phosphodiesterase 1C, calmodulin-dependent 70kDa FLJ40288 7q32.3 hypothetical protein FLJ40288 FLJ20420 LOC392882 7 similar to PRPS2 protein LOC392883 7 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) LSM5 7p14.3 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) KIAA0241 7p14.3 KIAA0241 protein LOC89231 7p14.3 LOC89231 LOC392989 7 hypothetical gene supported by AK130770; NM_003932 LOC392012 7 similar to PRPS2 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2175 - 337 wide/medium-field GABAergic amacrine cells and narrow-field glycinergic amacrine cells - 2174347
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific Homo sapiens
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualamacrine cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text central nervous system (
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • poly Glu
  • nuclear localization signal (NLS)
  • DNA binding basic domain
  • helix-loop-helix motif
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to Neurod6, Mus musculus
    ortholog to Neurod6, Rattus norvegicus
    ortholog to NEUROD6, Pan troglodytes
    Homologene
    FAMILY NEUROD family of basic helix-loop-helix transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • Has the ability to trigger neuronal differentiation of PC12 cells in the absence of neurotrophic factor, plays an important role in neurite outgrowth and has the capacity to regenerate neurite outgrowth in the absence of nerve growth factor (
  • Modulates a wide spectrum of genes with diverse functions, many of them being key downstream regulators of the NGF pathway, and critical to neuritogenesis, such as microtubules, microtubule-associated proteins and intermediate filaments (
  • Neuritogenesis and regeneration (
  • Links neuronal differentiation to survival via the network of molecular chaperones and endows the cells with increased stress tolerance (
  • Stimulates maximal mitochondrial mass at the lamellipodia stage, thus preceding axonal growth, triggers remodelling of the actin and microtubule networks in conjunction with increased expression of the motor protein KIF5B, thus promoting mitochondrial movement in developing neurites with accumulation in growth cones (
  • Plays an integrative role in co-ordinating increase in mitochondrial mass with cytoskeletal remodelling and may be a co-regulator of neuronal differentiation and energy metabolism (
  • A regulator of ROS homoeostasis, resulting in enhanced tolerance to oxidative stress (
  • Regulates with AT-rich-sequence-binding protein 2 a postmitotic cell fate choice between wide/medium-field GABAergic amacrine cells and narrow-field glycinergic amacrine cells subtypes (
  • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • directly regulates LPPR4 expression and the NEUROD6 -LPPR4 cascade plays an important role in neurite outgrowth
  • upon stress, NEUROD6 promotes colocalization of BCL2L2 with mitochondria and endoplasmic reticulum
  • NEUROD4 and NEUROD6 are factors that are closely related to NEUROD1 and NEUROD2
  • cell & other
    REGULATION
    activated by dimerization with another BHLH protein
    induced by auto-transactivation (NEUROD6)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS