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FLASH GENE
Symbol NEURL4 contributors: mct - updated : 20-10-2015
HGNC name neuralized homolog 4 (Drosophila)
HGNC id 34410
Location 17p13.1      Physical location : 7.218.950 - 7.232.638
Synonym name
  • neuralized-like protein 4
  • DNA
    TYPE functioning gene
    STRUCTURE 13.69 kb     29 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 5211 - 1560 - -
    29 - 5217 - 1562 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • centriole
  • HERC2 and NEURL4 localize to the centrosome
  • basic FUNCTION
  • promotes ubiquitylation of CCP110, thereby destabilizing this protein
  • counteracts accumulation of CCP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic MTOCs (microtubular organizing centres)
  • is a protein that interacts with CCP110, a centrosomal protein that regulates centrosome duplication
  • centrosome-targeted NEURL4 was sufficient to restore ciliogenesis in cells with manipulated daughter centrioles
  • early during ciliogenesis, NEURL4 transiently associated with the mother centriole in a process that required mother-daughter centriole proximity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HERC2 and the neuralized homologue NEURL4 are novel interaction partners of the centrosomal protein CCP110, and association between CCP110 and HERC2 depends on nonoverlapping regions of NEURL4
  • interacts with CCP110, a centrosomal protein that regulates centrosome duplication
  • several new UBE3A-interacting proteins, including HIF1AN, NEURL4, and mitogen-activated protein kinase 6 (MAPK6)
  • daughter centriole promotes ciliogenesis through NEURL4-dependent regulation of CP110 levels at the mother centriole
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS