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FLASH GENE
Symbol NEURL2 contributors: mct - updated : 28-01-2014
HGNC name neuralized-like 2 (Drosophila)
HGNC id 16156
Location 20q13.12      Physical location : 44.517.266 - 44.519.901
Synonym name
  • neuralized-like 2
  • chromosome 20 open reading frame 163
  • Synonym symbol(s) FLJ30259, dJ337O18.6, C20orf163, Ozz-E3, OZZ, NEUR2
    DNA
    TYPE functioning gene
    STRUCTURE 2.82 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1440 - 285 - -
    2 - 1454 - 261 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiensFetal
     brainlimbic systemhippocampus   Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    SOCS box (suppressor of cytokine signaling)
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    text
  • has a predominantly cytoplasmic localization
  • basic FUNCTION
  • muscle-specific ubiquitin ligase adaptor that regulates myofibril organization
  • function in ubiquitination and degradation of membrane-bound, but not cytosolic, beta-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers
  • developmentally regulated protein that functions as the adaptor component of a RING-type ubiquitin ligase complex specific to striated muscle
  • substrate-binding component of the muscle-specific ubiquitin ligase complex NEURL2-E3
  • plays an active role in myofiber differentiation and maturation, during embryogenesis and muscle regeneration
  • having distinct functions to maintain the integrity of at least two cell compartments, containing actin filaments, the sarcolemmal-associated cortical cytoskeleton and the sarcomere
  • may exert a dual function toward PDCD6IP, modulating its conformation and ubiquitination status
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with Notch ligands DLL1 and JAG1
  • NEURL and NEURL2 interact with another Notch ligand, DLL4
  • interacts with and regulates myosin within its fully assembled cytoskeletal structure
  • NEURL2 ligase regulates PDCD6IP at sites where the actin cytoskeleton undergoes remodeling
  • PDCD6IP is a bona fide interacting partner of NEURL2 and interaction between the two native proteins occurs in the differentiated muscle fibers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS