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Symbol NEURL1B contributors: SGE/npt - updated : 07-01-2010
HGNC name neuralized homolog 1B (Drosophila)
HGNC id 35422
Location 5q35.1      Physical location : 172.068.275 - 172.118.531
Synonym name
  • neuralized-2
  • neuralized-like protein 3
  • neuralized 2 alternative protein
  • E3 ubiquitin-protein ligase NEURL3
    • Synonym symbol(s) NEUR2, NEURL3, hNeur2, DKFZp761M1511
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 50.26 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 6417 - 555 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly expressed during embryogenic development of the brain and several non-neural tissues, and its mRNA levels subside postnatally (Rullinkov 2009)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two NHR domains
  • one RING-type zinc finger
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text in the hippocampal neurons of adult brain, NEURL1B is excluded from the dendrites (Rullinkov 2009)
    basic FUNCTION
  • ligase activity
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
    • protein
  • interacting with the Notch ligands Delta-like 1, Jagged 1 and Delta-like 4 (Rullinkov 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS