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FLASH GENE
Symbol NEU4 contributors: mct - updated : 03-12-2012
HGNC name sialidase 4
HGNC id 21328
Location 2q37.3      Physical location : 242.750.159 - 242.758.739
Synonym symbol(s) MGC18222, LP5125
EC.number 3.2.1.18
DNA
TYPE functioning gene
STRUCTURE 8.58 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located flanked on the telomeric side by the GAL3ST2 gene and on the centromeric side by DTYMK gene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2056 - 484 - 2004 14962670
4 - 2053 - 484 - 2004 14962670
  • NEU4 short (NEU4S)
  • NEU4 long and NEU4 short, differing in the presence of a 12-amino-acid sequence at the N-terminus
  • 5 - 2551 - 484 - 2004 14962670
    4 - 2373 - 497 - 2004 14962670
    4 - 2370 - 496 - 2012 22287118
  • NEU4 long (NEU4L)
  • its overexpression promotes CTNNB1 signaling in neuroblastoma cells, enhancing stem-like malignant cell growth
  • NEU4 long and NEU4 short, differing in the presence of a 12-amino-acid sequence at the N-terminus
  • potentially bound to the outer mitochondrial membrane
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     liver   predominantly
    Nervousbrainforebraincerebral cortex  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative transmembrane regions
  • three BNR repeats
  • typical sialidase amino-acid motifs
  • three potential O-glycosylation sites and several phosphorylation sites
  • HOMOLOGY
    intraspecies homolog to NEU2
    Homologene
    FAMILY
  • family 33 of glycosyl hydrolases, neuraminidases family
  • sialidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • removes sialic acid residues from glycoproteins and glycolipids
  • playing a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates
  • is potentially a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs
  • is potentially involved in regulation of neuronal function by polysialic acid degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS