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FLASH GENE
Symbol NEU4 contributors: mct - updated : 03-12-2012
HGNC name sialidase 4
HGNC id 21328
Location 2q37.3      Physical location : 242.750.159 - 242.758.739
Synonym symbol(s) MGC18222, LP5125
EC.number 3.2.1.18
DNA
TYPE functioning gene
STRUCTURE 8.58 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GPC1 2q37.3 glypican 1 ANKMY1 2q37.3 ankyrin repeat and MYND domain containing 1 LOC285193 2q37.3 similar to RIKEN cDNA 0710001B24 RNPEPL1 2q37.3 arginyl aminopeptidase (aminopeptidase B)-like 1 CAPN10 2q37.3 calpain 10 GPR35 2q37.3 G protein-coupled receptor 35 LOC285192 2q37.3 similar to aquaporin 11 AQP12 2q37.3 aquaporin 12 ATSV 2q37.3 axonal transport of synaptic vesicles AGXT 2q37.3 alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) FLJ22671 2q37.3 hypothetical protein FLJ22671 LOC285188 2q37.3 similar to KIAA0445 protein FLJ00133 2q37.3 FLJ00133 protein MGC61716 2q37.3 hypothetical protein MGC61716 PASK 2q37.3 PAS domain containing serine/threonine kinase PPP1R7 2q37.3 protein phosphatase 1, regulatory subunit 7 LOC344525 2q37.3 similar to transmembrane protein 16C; chromosome 11 open reading frame 25 HDLBP 2q37.3 high density lipoprotein binding protein (vigilin) NEDD5 2q37. neural precursor cell expressed, developmentally down-regulated 5 FARP2 2q37.3 FERM, RhoGEF and pleckstrin domain protein 2 STK25 2q37.3 serine/threonine kinase 25 (STE20 homolog, yeast) BOK 2q37.3 BCL2-related ovarian killer LOC391498 2 similar to Involucrin THAP4 2q37.3 THAP domain containing 4 APG4B 2q37.3 cysteine endopeptidase AUT-like isoform 1 DTYMK 2pter-p25.2 deoxythymidylate kinase (thymidylate kinase) ING5 2q37.3 inhibitor of growth family, member 5 GP3ST 2q37.3 inhibitor of growth family, member 5 NEU4 2q37.3 sialidase 4 LOC391499 ATTS1136 similar to EST gb FLJ38379 2q37.3 hypothetical protein FLJ38379 LOC159176 2q37.3 similar to F-box only protein 25
regionally located flanked on the telomeric side by the GAL3ST2 gene and on the centromeric side by DTYMK gene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2056 - 484 - 2004 14962670
4 - 2053 - 484 - 2004 14962670
  • NEU4 short (NEU4S)
  • NEU4 long and NEU4 short, differing in the presence of a 12-amino-acid sequence at the N-terminus
  • 5 - 2551 - 484 - 2004 14962670
    4 - 2373 - 497 - 2004 14962670
    4 - 2370 - 496 - 2012 22287118
  • NEU4 long (NEU4L)
  • its overexpression promotes CTNNB1 signaling in neuroblastoma cells, enhancing stem-like malignant cell growth
  • NEU4 long and NEU4 short, differing in the presence of a 12-amino-acid sequence at the N-terminus
  • potentially bound to the outer mitochondrial membrane
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     liver   predominantly
    Nervousbrainforebraincerebral cortex  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative transmembrane regions
  • three BNR repeats
  • typical sialidase amino-acid motifs
  • three potential O-glycosylation sites and several phosphorylation sites
  • HOMOLOGY
    intraspecies homolog to NEU2
    Homologene
    FAMILY
  • family 33 of glycosyl hydrolases, neuraminidases family
  • sialidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • removes sialic acid residues from glycoproteins and glycolipids
  • playing a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates
  • is potentially a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs
  • is potentially involved in regulation of neuronal function by polysialic acid degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS