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FLASH GENE
Symbol NEU3 contributors: mct/pgu - updated : 24-06-2015
HGNC name sialidase 3 (membrane sialidase)
HGNC id 7760
Location 11q13.4      Physical location : 74.699.949 - 74.718.741
Synonym name
  • N-acetyl-alpha-neuraminidase 3
  • ganglioside sialidase
  • neuraminidase 3
  • Synonym symbol(s) SIAL3, FLJ12388
    EC.number 3.2.1.18
    DNA
    TYPE functioning gene
    STRUCTURE 18.80 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029 KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene WNT11 11q13.5 wingless-type MMTV integration site family, member 11 PRKRIR 11q13.5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2748 - 461 - 2002 12011038
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Reproductivefemale systembreastmammary gland  
     male systemtestis  highly Homo sapiens
    Respiratorylungalveolar duct    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative transmembrane helix
  • the F/YRTP motif in N terminal region conserved in all sialidases
  • three Asp boxes (S-X-D-X-G-X-X-T/W)
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyl hydrolase 33 family, neuraminidases family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope,int
    text
  • cholesterol and lipid enriched microdomain lipid rafts
  • besides its localization at the plasma membrane, is present in intracellular structures at least partially represented by a subset of the endosomal compartment
  • detected both in the cytosol and nucleus
  • located in the inner membrane of nuclear envelope
  • NEU1 and NEU3 are present on erythrocyte plasma membrane
  • basic FUNCTION
  • key enzyme for ganglioside degradation, hydrolyzing gangliosides
  • functions as a caveolin-related signaling molecule within caveolin-rich microdomains
  • hving a critical regulatory function on the sialoglycosphingolipid pattern of the cell membrane, with an anti-apoptotic function, especially in cancer cells
  • able to mobilize to membrane ruffles in response to growth stimuli and activate the RAC1 signaling by co-localization with RAC1, leading to increased cell motility
  • differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signaling
  • modulates cell-surface biological events and plays a pivotal role in different cellular processes, including cell adhesion, recognition and differentiation
  • modulates the ganglioside content of adjacent cells with special regard to GM3 concentration, thus governing the cell-to-cell signaling program required for skeletal muscle differentiation
  • key enzyme for the extralysosomal catabolism of gangliosides
  • membrane-associated enzyme that cleaves glycolipid substrates
  • NEU1 restrains endothelial cell migration, whereas NEU3 does not
  • physiological role in protecting cells from hypoxic stress, suggesting potential new directions in the development of therapeutic strategies against ischemic diseases, particularly of the cerebro-cardiovascular system
  • besides the already reported indirect EGFR activation through GM3, sialidase NEU3 could also play a role on EGFR activation through its desialylation
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling signal transduction
    transmembrane signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enriched in caveolae microdomains and closely associates with caveolin like other caveolin-binding signaling molecules
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancers, leading to apoptosis suppression
    tumoral     --over  
    in colon cancer (epithelial cells), resulting in inhibition of apoptosis accompanied by increased BCL2 and decreased caspase expression
    tumoral     --over  
    in many types of cancers including colon and renal carcinomas and suppresses apoptosis of cancer cells
    constitutional     --over  
    significantly enhances cell resistance to hypoxia, whereas stable silencing of the enzyme renders cells more susceptible to apoptosis
    constitutional     --low  
    in sperm of some male idiopathic infertility cases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • could represent a new potent biomarker in childhood ALL, to assess the efficacy of therapeutic protocols and to rapidly identify an eventual relapse
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    siRNAs targeting this protein could have utility for gene-based therapy of cancer
    cancer  
    may be a potential target for cancer diagnosis and therapy
    ANIMAL & CELL MODELS