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FLASH GENE
Symbol NETO2 contributors: mct - updated : 20-12-2014
HGNC name neuropilin (NRP) and tolloid (TLL)-like 2
HGNC id 14644
Location 16q12.1      Physical location : 47.115.441 - 47.177.908
Synonym name brain-specific transmembrane protein containing CUB domain 2
Synonym symbol(s) FLJ10430, NEOT2, FLJ14724, FLJ90456, BTCL2
DNA
TYPE functioning gene
STRUCTURE 62.47 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3653 - 525 - 2002 11943477
EXPRESSION
Rna function mRNAs were observed restrictively in brain throughout embryonic and postnatal stages, uniquely in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral lobefrontal  Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
  • a transmembrane domain
  • an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis
    • HOMOLOGY
    interspecies homolog to murine Neto2
    intraspecies homolog to NETO1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • implicated in intracellular signaling pathway
  • having roles during development of the central nervous system
  • kainate receptor subunit with significant effects on glutamate signaling mechanisms in brain
  • involved in neural and vascular patterning
  • have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
  • NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
  • NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
  • is a SLC12A5 interacting protein required for neuronal Cl- regulation in hippocampal neurons
  • NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactor with kainate-type glutamate receptors
  • modulates the gating kinetics of GRIK2, and the function of most kainate receptors
  • in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2
  • is required to maintain the normal abundance of SLC12A5 and specifically associates with the active oligomeric form of the transporter)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in proliferating hemangiomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS