basic FUNCTION
| guanine nucleotide exchange factors (GEFs) specific for RhoA, but not CDC42 or RAC1 |
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having ability to stimulate cytoskeletal reorganization and to transform cells |
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acting as guanine nucleotide exchange factor (GEF) for RhoA GTPase |
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may be involved in activation of the SAPK/JNK pathway |
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importance of NET1 in controlling RHOA and MAPK14 mediated cell survival in cells exposed to DNA damaging agents |
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driver of tumour cell invasion, an activity mediated by RhoA activation and cytoskeletal reorganisation |
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requires interaction with PDZ domain proteins, such as DLG1, to protect it from proteasome-mediated degradation and to maximally stimulate RHOA and that this interaction is regulated by cell-cell contact |
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guanine nucleotide exchange factor of RHOA, critical for TGF-beta1-induced cytoskeletal reorganization, N-cadherin expression, and RHOA activation |
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nuclear guanine nucleotide exchange factors ECT2 and NET1 regulate RHOB-mediated cell death after DNA damage |
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might potentially have a previously unidentified function in the nucleus of cells |
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functional NET1/RHOA signaling pathway within the nucleus of the cell and implicate them in the DNA damage response |
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required for chromosome congression during metaphase and generation of stable kinetochore microtubule attachments |
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is a novel regulator of mitosis, indicating that altered expression of NET1, as occurs in human cancers, may adversely affect genomic stability |