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FLASH GENE

Symbol

NES

contributors: npt/mct/shn - updated : 01/11/2012

HGNC name	nestin
HGNC id	7756

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q22      Physical location : 156.638.556 - 156.647.189
Synonym name	nestin, cytoplasmic intermediate filament of central nervous system
Synonym symbol(s)	FLJ21841, Nbla00170

DNA

TYPE	functioning gene
STRUCTURE	8.63 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D1S2721 - D1S2624 - NES - D1S506 - D1S1600 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006617 4 - 5591 NP_006608 - 1621 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus dentate gyrus predominantly Homo sapiens NM_006617

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining neuroepithelium

cell lineage
cell lines	expressed in tumors of the central and peripheral nervous systems, in endothelial cells and in some muscle cells adjacent to tumors
fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	developing central nervous system

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to NES, Pan troglodytes
	ortholog to Nes, Mus musculus
	ortholog to nes, Danio rerio
	ortholog to Nes, Rattus norvegicus

Homologene

FAMILY

intermediate filament family, type IV

CATEGORY

motor/contractile , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament

basic FUNCTION	playing a role in nervous system development and upon terminal neural differentiation, downregulated and replaced by neurofilaments
	selective marker of the basal breast cancer phenotype, which displays features of mammary progenitors
	having a function in cell motility
	serves as a scaffold for Cdk5
	required for acetylcholine-induced, Cdk5-dependent dispersion of acetylcholine-receptor clusters during neuromuscular junction development (

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	cdk5 and p35 kinase
	cyclin-dependent kinase 5, CDK5

cell & other

REGULATION

Phosphorylated by

cdc2 kinase

Other

cyclin-dependent kinase 5, CDK5 (

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer cells from patients with lethal androgen-independent disease

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

nestin-deficient mice have a normal development of the central nervous system but show impaired motor coordination the number of acetylcholine receptor clusters, the nerve length, and the endplate bandwidth are significantly increased in neuromuscular junction area