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FLASH GENE
Symbol NENF contributors: shn/npt - updated : 09-05-2009
HGNC name neuron derived neurotrophic factor
HGNC id 30384
Location 1q32.3      Physical location : 212.606.228 - 212.619.719
Synonym name
  • SCIRP10-related protein
  • spinal cord injury related protein 10
  • cell growth-inhibiting protein 47
  • neudesin
  • cell immortalization-related protein 2
  • secreted protein of unknown function
  • neuron-derived neurotrophic factor
  • SPUF protein
  • Synonym symbol(s) CIR2, SCIRP10, SPUF, NEUDESIN
    DNA
    TYPE functioning gene
    STRUCTURE 13.49 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map based on a sequence alignment, the NENF gene has been mapped to 1q32.3 cen - D1S2780 - D1S425 - NENF - D1S505 - D1S1667 - qter
    Authors Scott (2008)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 995 15.6 172 brain and white adipose tissue Kimura (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouth   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text in mice, in situ hybridization showed abundant expression of neudesin in developing brain and spinal cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 24-amino acid signal peptide
  • a predicted cytochrome b5-like heme/steroid-binding domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Nenf, Mus musculus
    ortholog to Nenf, Rattus norvegicus
    ortholog to NENF, Pan troglodytes
    ortholog to nenf, Danio rerio
    Homologene
    FAMILY
  • cytochrome b5 family
  • MAPR subfamily
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may play a role in neuron differentiation and development
  • first extracellular heme-binding protein found to be involved in intercellular signal transduction
  • encodes a secreted signal with neurotrophic activity in neurons
  • playing a potential role in neural cell proliferation, neuronal differentiation and inhibited differentiation of astrocytes
  • Fe(III)-protoporphyrin IX is required for its neurotrophic activity
  • may be involved in intercellular signal transduction
  • neudesin promotes neural precursor cell proliferation early in the developmental process via the MAPK and PI3 kinase pathways
  • neudesin suppresses adipogenesis in the early stage of adipocyte differentiation, suggesting that neudesin may play an important role in adipogenesis by controlling the MAPK pathway
  • potentially involved in neural development (Miyake 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS extracellular transport , cell to cell transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • the NENF protein binds heme
  • protein
  • binds hemin (hemin bound to the cytochrome b5-like heme/steroid-binding domain)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS