motifs/domains
| N terminal signal peptide and thrombospondin I-like domain (TSP-N), important for intermolecular binding of NELL2, and for binding to heparin, and N-terminal 29 AAs of NELL2 were important for secretion |
|
five von Willebrand factor C domains (VWC) |
|
five CR domains |
|
six calcium binding EGF-like repeats, that could be involved in the secretion mechanism of NELL2 and three of the six EGF-like domains contain the residues required for Ca2+ binding, suggesting that NELL2 may act as a Ca2+-dependent signaling molecule (Kim 2010) |
|
three additional cysteine-rich domains, playing major roles in NELL2-induced growth cone collapse of retinal axons |
SUBCELLULAR LOCALIZATION
| extracellular
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic,vesicle
|
text
| secreted |
|
found in the cytoplasm of neurons, but not in glial fibrillary acidic protein (GFAP)-positive glial cells (Jeong 2008) |
basic FUNCTION
| involved in the growth and differentiation of neural cells |
|
playing a potential oncogenic role in neural cells |
|
promotes survival of neurons by modulating MAPK activities (Aihara 2003) |
|
dual functions in both the cell autonomous differentiation of neural progenitor cells while simultaneously exerting paracrine proliferative activity (Nelson 2004) |
|
neural tissue-enriched protein, produced in the embryo, and postembryonically in the mammalian brain, with a broad distribution (Jeong 2008) |
|
new component of glutamatergic neurons and provide evidence for its physiological involvement in a major, glutamate-dependent, process of neuroendocrine regulation (Ha 2008) |
|
secreted protein that promotes neuronal survival and differentiation (Kim 2010) |
|
potential mediator of estrogen-induced neuronal survival in the central nervous system |
|
is involved in the maintenance of the normal female reproductive cycle in mammals |
|
play crucial roles in development and functioning of the nervous system |
|
important regulator of neural development and functions |
|
having an alternative splicing form that encodes cytoplasmic protein, may regulate intracellular signaling through its EGF-like repeats |
|
novel activity for NELL2 in cancer progression through the regulation of E2F1 |
|
may affect the cellular activity of cells in a paracrine or autocrine manner |