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FLASH GENE

Symbol

NELF

contributors: mct/npt - updated : 14-06-2008

HGNC name	nasal embryonic LHRH factor
HGNC id	29843

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HHI2 hypogonadism, isolated hypogonadotropic, 2
Location	9q34.3      Physical location : 140.342.024 - 140.353.786
Synonym name	nasal embryonic luteinizing hormone-releasing hormone factor
Synonym symbol(s)	RP11-48C7.1, MGC125369

DNA

TYPE	functioning gene
STRUCTURE	11.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 5 - splicing 2987 variant 5 - 530 - Miura, 2004 variant 1 15 splicing 2972 variant 1 59.9 528 - Miura (2004), Lim (2007) variant 2 - splicing 2918 variant 2 - 507 - Miura, 2004 variant 3 - splicing 2897 variant 3 - 500 - Miura, 2004 variant 4 - splicing 3223 variant 4 - 402 - Miura, 2004

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   salivary gland       highly   stomach       highly Nervous nerve       highly Reproductive female system uterus cervix   highly   male system testis     highly Skeleton         moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage
cell lines	meningioma
	moderately differentiated adenocarcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Nelf
	ortholog to rattus Nelf

Homologene

FAMILY

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

playing a role as a common guidance molecule for olfactory axon projections in the neurophilic migration of LHRH cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HHI2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS