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FLASH GENE
Symbol NEK4 contributors: mct - updated : 12-12-2012
HGNC name NIMA (never in mitosis gene a)-related kinase 4
HGNC id 11399
Location 3p21.1      Physical location : 52.744.795 - 52.804.965
Synonym name
  • serine/threonine kinase 2
  • serine/threonine-protein kinase NRK2
  • Synonym symbol(s) NRK2, STK2, pp12301, MGC33171
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 60.17 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3745 94.6 841 - 2012 22851694
    15 - 3478 - 752 - 2012 22851694
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    Urinarykidney   lowly Homo sapiens
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines cervical cancer cell lines, breast cancer
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • protein kinase domain
  • ATP binding sites
  • autophosphorylation (T165) site
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Nek4
    homolog to C.elegans Y39G10AR.4
    intraspecies homolog to NEK11, which is required for DNA damage-induced G2/M arrest
    Homologene
    FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • never in mitosis A (NIMA)-related protein kinase (Nek) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus
    text
  • in ciliated cells, localized to basal bodies, while in ciliated organs, the kinase was predominantly detected at the ciliary rootlet
  • basic FUNCTION
  • acting as a serineL/threonine kinase
  • role in cilium dynamics
  • prominently decorates the base of the cilium and associates with ciliary rootlets, structures that are essential for ciliary stability
  • implicated as a novel regulator of replicative senescence and the response to double-stranded DNA damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • RPGRIP1 and RPGRIP1L function as scaffolds that recruit NEK4, its substrates and its regulators to their active site in the cilium, thus maintaining cilium integrity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    NEK4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • ciliopathy candidate gene
  • Marker
    Therapy target
    ANIMAL & CELL MODELS