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FLASH GENE
Symbol NEK3 contributors: - updated : 06-06-2006
HGNC name NIMA (never in mitosis gene a)-related kinase 3
HGNC id 7746
Location 13q14.13      Physical location : 52.706.779 - 52.733.996
Synonym symbol(s) HSPK36
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D13S153 - D13S284 - NEK3 - D13S163 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
text
  • three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2332 57 506 - -
  • 16 exons
  • encoding the same protein that variant 2
  • - splicing 2255 57 506 - -
  • 16 exons
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein that variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon moderately
    Hearing/Equilibriumear   predominantly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  moderately
    Urinarykidney   moderately
    cell lineage
    cell lines proliferating cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text widely, in a non dependent cell cycle pattern
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve conserved regions characteristic of protein kinase catalytic domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Aspergillus nidulans NIMA
    homolog to rattus Nek3 (75.4pc)
    homolog to murine Nek3 (75.1pc)
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    basic FUNCTION
  • may play a role in mitotic regulation
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • Mg2+
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS