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FLASH GENE
Symbol NEK11 contributors: SGE/npt - updated : 08-06-2010
HGNC name NIMA (never in mitosis gene a)- related kinase 11
HGNC id 18593
Location 3q22.1      Physical location : 130.745.693 - 131.069.308
Synonym name NimA-related protein kinase 11
Synonym symbol(s) FLJ23495
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 323.58 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF9 3p13.3-q24 zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) COPG 3q21.3 coatomer protein complex, subunit gamma DC12 3q21.3 DC12 protein H1FX 3q21.3 H1 histone family, member X LOC90288 3q21.3 hypothetical protein LOC90288 MBD4 3q21-q22 methyl-CpG binding domain protein 4 WDR10 3q21 WD repeat domain 10 RHO 3q21.3-q24 rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) H1FOO 3q21.3 H1 histone family, member O, oocyte-specific PLXND1 3q21.3 plexin D1 KIAA0779 3q21.3 plexin D1 TRH 3q13.3-q21 thyrotropin-releasing hormone LOC391576 3 hypothetical gene supported by AK122996 LOC285407 3q21.3 similar to mannosyltransferase LOC339944 3q21.3 similar to hypothetical protein FLJ10661 LOC389148 3 LOC389148 FLJ35880 3q22.1 hypothetical protein FLJ35880 LOC131873 3q22.1 hypothetical protein LOC131873 PIK3R4 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4, p150 GSTO3P1 3q22.1 glutathione S-transferase omega 3 pseudogene 1 ATP2C1 3q21 ATPase, Ca++ transporting, type 2C, member 1 HT001 3q22.1 HT001 protein NEK11 3q21.3 NIMA (never in mitosis gene a)- related kinase 11 LOC152195 3q22.1 hypothetical protein LOC152195 LOC389149 3 LOC389149 FLJ31265 3q22.1 hypothetical protein FLJ31265 MRPL3 3q21.2-q23 mitochondrial ribosomal protein L3 CPNE4 3q22.1 copine IV LOC344568 3q22.1 similar to proteasome (prosome, macropain) 26S subunit, ATPase 2; Proteasome (prosome, macropain) 26S subunit, ATPase LOC391577 3 similar to ribosomal protein L7 ACPP 3q21.3-q23 acid phosphatase, prostate LOC131039 3q22.1 similar to Saccharomyces cerevisiae Nip7p homolog RME8 3q22.1 RME8 protein FLJ12592 3q22.1 putative acyl-CoA dehydrogenase CCRL1 3q22 chemokine (C-C motif) receptor-like 1 UBE1DC1 3q22 ubiquitin-activating enzyme E1-domain containing 1 NPHP3 3q22.1 nephronophthisis 3 (adolescent)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing 2963 74.1 645 - Noguchi (2002)
  • isoform 1
  • NEK11L
  • 15 splicing 2107 54 470 - Noguchi (2002)
  • isoform 2
  • NEK11S
  • - - 2793 68.7 599 - Noguchi (2002)
  • isoform 3
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecaecumappendix vermicularlowly
    Endocrinepancreas    
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrainhindbraincerebellum lowly
    Reproductivefemale systemuterus  lowly
    Respiratorylung   lowly
     respiratory tracttrachea  lowly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S, G2, checkpoint, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one protein kinase domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Nek11 (76.6pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having a protein serine/threonine kinase activity
  • critical kinase triggering CDC25A degradation by directly phosphorylating it and thus leading to its polyubiquitylation and degradation (Sorensen 2010)
  • has a role in S phase checkpoint downstream of ATR/ATM signaling (Noguchi 2002)
  • phosphorylating histone H1, H2A, H3, H2B and H4
  • NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • nucleolar complex formed by NEK11 and NEK2A, increased in G1/S arrested cells (Noguchi 2004)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • activity enhanced by Mn2+
  • ATP
  • protein
  • histone H1, histone H2A, histone H3 (H2B,H4)
  • MBP
  • associating with NEK2A (Noguchi 2004)
  • cell & other
    REGULATION
    activated by DNA replication and genotoxic stresses
    phosphorylation on ser273 by CHEK1 (Sorensen 2010)
    inhibited by Zn2+, NaCl
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    expression increased during colon cancer development (Sorensen 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target inhibition of NEK11 forces checkpoint-arrested cells into mitosis and cell death, and thus is a potential target for the development of novel anticancer drugs (Sorensen 2010)
    ANIMAL & CELL MODELS