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FLASH GENE
Symbol NEK10 contributors: mct - updated : 30-08-2012
HGNC name NIMA (never in mitosis gene a)- related kinase 10
HGNC id 18592
Location 3p24.1      Physical location : 27.257.097 - 27.410.912
Synonym symbol(s) FLJ32685
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 153.82 kb     25 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 2656 - 712 - 2011 20956560
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a centrally located catalytic domain as well as four N-terminal armadillo repeats
  • flanked by coiled-coiled repeats and a putative PEST sequence near the C terminus
  • HOMOLOGY
    Homologene
    FAMILY Nek (NIMA-related kinase) family of serine/threonine protein kinases
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • role in the maintenance of the G2/M checkpoint following UV irradiation, and in the cellular UV response
  • required for the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling upon UV irradiation but not in response to mitogens, such as epidermal growth factor stimulation
  • plays a role in maintenance of the G2/M checkpoint following UV irradiation
  • NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RBMY1A1 (RBMY1A1 protein can only bind to transcript variant 2 of NEK10 and RBMY1A1 may take part in alternative splicing of NEK10)
  • physically associated with RAF1 and MEK1 in a RAF1-dependent manner, and the formation of this complex was necessary for NEK10-mediated MAP2K1 activation
  • MAP2K1 may contribute to the stability of the NEK10/RAF1 interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS