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FLASH GENE
Symbol NEIL3 contributors: mct/npt - updated : 21-10-2014
HGNC name nei endonuclease VIII-like 3 (E. coli)
HGNC id 24573
Location 4q34.3      Physical location : 178.230.990 - 178.284.092
Synonym name
  • DNA glycosylase hFPG2
  • Nei-like 3
  • Synonym symbol(s) FPG2, FLJ10858, NEI3
    EC.number 4.2.99.18
    DNA
    TYPE functioning gene
    STRUCTURE 53.10 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2402 - 605 - Morland (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Lymphoid/Immunethymus    
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RAN-binding protein -like zinc finger motif
  • an N-terminal Nei-like domain
  • putative NEIL3 glycosylase domain (1-290 aa)
  • C-terminal zinc ribbon domain, a long C-terminal extension with unique structural features (Liu 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • FPG family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • initiating the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction
  • seems to be highly expressed in cells with high proliferative potential (Hildrestrand 2009)
  • its function might be required in proliferating cells to remove lethal and mutagenic lesions from the genome (Liu 2010)
  • exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells
  • DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells
  • NEIL3-dependent repair of oxidative DNA damage in neural stem/progenitor cells is required for maintenance of adult neurogenesis to counteract the age-associated deterioration of cognitive performance
  • functional DNA glycosylase having a different substrate specificity and unusual structural features compared with other Fpg/Nei homologs
  • is one of the four DNA glycosylases found to recognize and remove hydantoins in the first step of base excision repair (BER) pathway
  • involvement in removal of replication blocks in proliferating cells
  • DNA glycosylase of the base excision repair pathway that protects cells from oxidative DNA damage by excising a broad spectrum of cytotoxic and mutagenic base lesions
  • exhibits an unusual preference for DNA with single-stranded regions
  • role for NEIL3 and NEIL1 is to repair DNA base damages in telomeres and NEIL3 and NEIL1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • hippocampal neurons in Neil3(-/-) mice display synaptic irregularities