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FLASH GENE
Symbol NEDD8 contributors: mct/npt/shn - updated : 31-05-2014
HGNC name neural precursor cell expressed, developmentally down-regulated 8
HGNC id 7732
Location 14q11.2      Physical location : 24.686.056 - 24.701.576
Synonym name
  • neddylin
  • ubiquitin-like protein Nedd8
  • Synonym symbol(s) NED8, Nedd-8, FLJ43224, MGC104393, MGC125896, MGC125897, APPBP1, NAE1
    DNA
    TYPE functioning gene
    STRUCTURE 15.52 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D14S581 - D14S64 - NEDD8 - D14S264 - D14S1041 - qter
    Physical map
    DHRS4 14q11.2-14q21.3 dehydrogenase/reductase (SDR family) member 4 DHRS4L2 14 dehydrogenase/reductase (SDR family) member 4 like 2 LOC387975 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase LOC90668 14q11.2 hypothetical protein BC008134 CPNE6 14q11.2 copine VI (neuronal) NRL 14q11.1-q11.2 neural retina leucine zipper PCK2 14q11.2-q12 phosphoenolpyruvate carboxykinase 2 (mitochondrial) WDR23 14q11.2 WD repeat domain 23 LOC161247 14q11.2 similar to 1110028A07Rik protein PSME1 14q11.2 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) C14orf122 14q11.2 chromosome 14 open reading frame 122 PSME2 14q11.2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) RNF31 14q11.2 ring finger protein 31 ISGF3G 14q11.2 interferon-stimulated transcription factor 3, gamma 48kDa REC8L1 14q11.2-q12 REC8-like 1 (yeast) IPO4 14q11.2 importin 4 TM9SF1 14q11.2 transmembrane 9 superfamily member 1 C14orf20 14q11.2 chromosome 14 open reading frame 20 C14orf123 14q11.2 chromosome 14 open reading frame 123 MGC5987 14q11.2 hypothetical protein MGC5987 NEDD8 14q11.2 neural precursor cell expressed, developmentally down-regulated 8 GMPR2 14q11.2 guanosine monophosphate reductase 2 TINF2 14q11.2 TERF1 (TRF1)-interacting nuclear factor 2 TGM1 14q11.2 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) RABGGTA 14q11.2 Rab geranylgeranyltransferase, alpha subunit DHRS1 14q11.2 dehydrogenase/reductase (SDR family) member 1 C14orf21 14q11.2 chromosome 14 open reading frame 21 CIDEB 14q11.2 cell death-inducing DFFA-like effector b LTB4R2 14q11.2-q12 leukotriene B4 receptor 2 LTB4R 14q11.2-q12 leukotriene B4 receptor ADCY4 14q11.2 adenylate cyclase 4 RIPK3 14q11.2 receptor-interacting serine-threonine kinase 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 625 8.9 81 - 2005 15567417
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestinesmall intestine  lowly Homo sapiens
     intestinelarge intestinecolon lowly Homo sapiens
     liver   lowly Homo sapiens
    Endocrinepancreas   lowly Homo sapiens
    Nervousbrain   lowly Homo sapiens
    Reproductivefemale systemovary  lowly Homo sapiens
     female systemplacenta  lowly Homo sapiens
    Respiratorylung   lowly Homo sapiens
    Urinarykidney   lowly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiens
    cell lineage neural precursor cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text moderately in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Nedd8, Rattus norvegicus
    ortholog to Nedd8, Mus musculus
    ortholog to nedd8, Danio rerio
    Homologene
    FAMILY
  • ubiquitin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as an ubiquitin-like protein playing an important role in cell cycle control and embryogenesis
  • regulating cell-cycle progression (targeting of katanin for degradation during transition from meiosis to mitosis)
  • involved in protecting a subset of ribosomal proteins from destabilization
  • interplay between NEDD8 and ubiquitin pathways operating in diverse cellular stress conditions
  • NEDD8 modification potentiates parkin E3 ligase activity
  • conserved role for NEDD8 in linking cullin-RING ubiquitin ligases (CRLs) ubiquitin ligase function to the VCP pathway
  • modifies cullin-RING ubiquitin E3 ligases
  • role of NEDD8 in regulating transcription factor stability and function
  • may play an important role in the control of proliferation and differentiation of human placenta throughout pregnancy
  • CELLULAR PROCESS cell cycle, progression
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • embryogenesis
  • morphogenesis
  • PATHWAY
    metabolism
    signaling
    a component
  • covalently conjugating to cullin 2 through the complex VHL-elongin B and elongin C
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ubiquitin C-terminal hydrolase, UCH-L3
  • culin 1, CUL1
  • NEDD8 Ultimate Buster-1, NUB1
  • ROC1-CUL1
  • aryl hydrocarbon receptor, AhR
  • negative regulator of ubiquitin-like proteins 1 like, NUB1L
  • ubiquitin-like protein FAT10
  • Ulp/Senp protease family member Den1
  • breast cancer-associated protein 3, BCA3
  • Cullin3, Cul3
  • crucial regulator of RPL11 signalling to TP53
  • NEDD8 is an ancillary player to regulate the stability of HIF1A
  • PRKN and PINK1 are NEDD8 conjugated
  • E2F1 is a substrate for NEDD8 post-translational modification (NEDDylation results in decreased E2F1 stability, lower transcriptional activity and slower cell growth)
  • NEDD8 is conjugated to RCAN1 (RCAN1-1S) via three lysine residues, K96, K104, and K107 (neddylation enhances RCAN1 protein stability without affecting its cellular location)
  • plays an important role in the ubiquitination of SCNN1A in alveolar epithelial cells
  • NUB1L directly interacted with NEDD8, but not with ubiquitin, on the key residue Asn-51 of NEDD8 and with VCP on its positively charged VCP binding motif
  • COPS5 acts potentially as a positive regulator of IFN responses by stabilizing IFNR through antagonizing the NEDD8 pathway
  • physically SMURF1 interacts with NEDD8 and UBE2M, forms a NEDD8-thioester intermediate, and then catalyses its own neddylation on multiple lysine residues
  • cell & other
    REGULATION
    activated by ubiquitin-activating (E1) enzyme
    Other modified by CUL1
    cleavage of precursor form by UCHL3 or SENP8 is necessary for function
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    NEDD8 conjugation process could be a potential target for cancer therapy
    ANIMAL & CELL MODELS