Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NEDD4 contributors: mct/npt - updated : 13-10-2016
HGNC name neural precursor cell expressed, developmentally down-regulated 4
HGNC id 7727
Location 15q21.3      Physical location : 56.119.130 - 56.285.835
Synonym name
  • cell proliferation-inducing gene 53 protein
  • receptor-potentiating factor 1
  • Synonym symbol(s) RPF1, KIAA0093, NED4, NEDD4-1, MGC176705
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 166.72 kb     29 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388123 15 LOC388123 FLJ38736 15q21.1 hypothetical protein FLJ38736 UNC13C 15q21.1 unc-13 homolog C (C. elegans) C15orf15 15q21 chromosome 15 open reading frame 15 RAB27A 15q15-q21.1 RAB27A, member RAS oncogene family PIGB 15q21-q22 phosphatidylinositol glycan, class B CPR8 15q21.1 phosphatidylinositol glycan, class B LOC145788 15q21.1 hypothetical LOC145788 DYX1C1 15q21 hypothetical LOC145788 PYGO1 15q21.1 pygopus 1 FLJ25756 15q21.1 hypothetical protein FLJ25756 NEDD4 15q15-q21.2 neural precursor cell expressed, developmentally down-regulated 4 FLJ12994 15q21.2 hypothetical protein FLJ12994 LOC390586 15 similar to L-3-hydroxyacyl-CoA dehydrogenase LOC161577 15q21.2 LOC161577 protein MNS1 15q21.2 meiosis-specific nuclear structural protein 1 FLJ20086 15q21.2 hypothetical protein FLJ20086 LOC145783 15q21.2 hypothetical protein LOC145783 TCF12 15q21 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) LOC388124 15 LOC388124 FLJ14957 15q21.2 hypothetical protein FLJ14957 FLJ30973 15q21.2 hypothetical protein FLJ30973 GRINL1A 15q22.1 glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A ALDH1A2 15q21.2 aldehyde dehydrogenase 1 family, member A2 AQP9 15q22.1-q22.2 aquaporin 9 LOC145780 15q21.2 hypothetical LOC145780 LIPC 15q21-q22.2 lipase, hepatic ADAM10 15q22 a disintegrin and metalloproteinase domain 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 7019 - 1247 - 2007 17218260
    29 - 5760 - 900 - 2007 17218260
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic developing nervous system, neural precursor cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Nedd4a
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • plays a critical role in dendrite formation
  • NEDD4 functions in conjunction with other post-translational mechanisms to regulate THOC1 protein and THO activity
  • E3 ligase inhibiting the activity of the Hippo pathway by targeting LATS1 for degradation
  • acts as an additional regulator of the Hippo pathway on the protein level via interactions between WW domain-containing and PPxY motif-containing proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • NEDD4/RAP2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons
  • a component
  • NEDD4, the serine/threonine kinase TNIK, and RAP2A form a complex that controls NEDD4-mediated ubiquitination of RAP2A
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MTMR4 is a novel interactor of the ubiquitin ligase NEDD4
  • NEDD4, NEDD4L and ITCH mediate poly-ubiquitination of AMOT/p130
  • mediates the ubiquitylation and degradation of the adapter protein dishevelled-1 (DVL1), the expression of which negatively regulates cell-cell contact
  • NEDD4 directly interacts with LATS1, leading to ubiquitination and decreased levels of LATS1 and, thus, increased YAP1 localization in the nucleus
  • NEDD4 constitutively interacts with CD40 and mediates K63-linked ubiquitination of TRAF3
  • ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2
  • E3 ubiquitin ligases NEDD4 and MARCH8 are regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes
  • cell & other
    REGULATION
    activated by RAC1(activated RAC1 stimulate NEDD4 activity, resulting in increased ubiquitylation of DVL1)
    calcium, that activates the E3 ubiquitin ligase activity of NEDD4
    inhibited by PTEN
    Other developmentally downregulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with NDFIP1 proteins are up-regulated in stressed neurons during brain injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    ubiquitination by NEDD4 targets SNCA to the endosomal-lysosomal pathway and, by reducing SNCA content, may help protect against the pathogenesis of Parkinsondisease and other alpha-synucleinopathies
    ANIMAL & CELL MODELS
  • disruption of Nedd4-1 in mice (leaving Nedd4-2 intact) caused embryonic lethality at mid gestation, with pronounced heart defects (double-outlet right ventricle and atrioventricular cushion defects) and vasculature abnormalities (Fouladkou 2010)