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FLASH GENE
Symbol NEDD1 contributors: mct - updated : 23-04-2020
HGNC name neural precursor cell expressed, developmentally down-regulated 1
HGNC id 7723
Location 12q23.1      Physical location : 97.301.000 - 97.347.461
Synonym symbol(s) FLJ35902, TUBGCP7, GCP-WD
DNA
TYPE functioning gene
STRUCTURE 46.47 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3977 - 660 - 2009 19243593
14 - 3738 - 571 - 2009 19243593
15 - 3724 - 660 - 2009 19243593
15 - 3805 - 667 - 2009 19243593
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainhindbrainmedulla oblongata  
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text embryo, strongly, in brain, fetal eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight WD40 repeats
  • C-terminal domain that binds TUBG1 has a helical structure and is a stable tetramer in solution
  • HOMOLOGY
    intraspecies homolog to GTP binding protein beta subunit
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a potential role as a tumor suppressor gene
  • may play an important role during the embryonic development and differentiation of the central nervous system
  • centriole duplication requires NEDD1-dependent recruitment of gamma-tubulin to the centrosome
  • may be a promising target for controlling cell proliferation, in particular if targeted in combination with PLK1 inhibitors
  • TUBG1 and its recruiting proteins (NEDD1 and CDK5RAP2) were localized at centrosomes of immature neurons, while they were lost at centrosomes in mature neurons
  • in the absence of AURKA, DLGAP5 and NEDD1 proteins that are involved in nucleation of microtubules fail to concentrate in the midzone
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of acentriolar oocyte microtubule-organizing centers, which functions in the regulation of meiotic spindle stability
  • member of the gamma-tubulin ring complex (gammaTuRC)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HAUS6 interacts with the NEDD1-gamma-tubulin complex and recruits this complex to the spindle, which, in turn, promotes microtubule polymerization
  • HAUS6 is a spindle-associated protein, promoting microtubule-dependent microtubule amplification through its interaction with and recruitment of NEDD1, the targeting subunit of the gamma-tubulin ring complex
  • binds directly to TUBG1 through a small region of just 62 AAs at the C-terminus of the protein
  • via the formation of the NEDD1-PLK1 complex and subsequent HAUS8 phosphorylation, PLK11 regulates spindle MT-based MT nucleation to accomplish normal bipolar spindle formation and mitotic progression
  • interaction with NEDD1 is necessary for the centrosome localization of CEP57
  • CEP192, a centrosomal protein similarly required for spindle formation, associates with NEDD1 and modulates its mitotic phosphorylation (also CEP192 may regulate spindle assembly by modulating NEDD1 function)
  • one important function of AURKA in mitotic cells is to promote MT nucleation around the chromatin by phosphorylating NEDD1, and thereby to promote functional spindle assembly
  • centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures that recruit other centrosomal proteins such as PCM1 and NEDD1
  • HSPA4 may associate with NEDD1 and TUBG1, two pericentriolar material (PCM) components essential for centrosome maturation and MT nucleation
  • MZT1 specifically binds fully assembled GTuRC to enable interaction with NEDD1 for targeting, and with the CM1 domain of CDK5RAP2 for stimulating nucleation activity
  • cell & other
  • binds to the gamma-tubulin ring complex, a multiprotein complex at the centrosome and at the mitotic spindle that mediates the nucleation of microtubules
  • REGULATION
    Phosphorylated by AURKA, that phosphorylates DLGAP5 and NEDD1 during assembly of the initial bipolar spindle
    Other developmentally downregulated
    regulated by CDK1 and PLK1 (sequential phosphorylation of by CDK1 and PLK1 plays a pivotal role in targeting gammaTuRC to the centrosome by promoting the interaction of NEDD1 with the gammaTuRC component gamma-tubulin, during mitosis)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS