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FLASH GENE
Symbol NECTIN4 contributors: mct - updated : 20-12-2016
HGNC name nectin cell adhesion molecule 4
HGNC id 19688
Corresponding disease
EDCS2 ectodermal dysplasia cutaneous syndactyly 2
Location 1q23.3      Physical location : -
Synonym name
  • Ig superfamily receptor LNIR
  • poliovirus receptor related 4
  • nectin4
  • Synonym symbol(s) LNIR, PRR4, PVRL4,
    DNA
    TYPE functioning gene
    STRUCTURE 18.61 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3520 - 510 - Reymond (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemplacenta  predominantly
    Respiratoryrespiratory tracttrachea   
    Skin/Tegumentskin   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig-like C2-type domains
  • one Ig-like V-type domain
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pvrl4 (92.3pc)
    homolog to rattus Pvrl4 (94.1pc)
    intraspecies homolog to PVR
    Homologene
    FAMILY
  • nectin family
  • CATEGORY adhesion , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction,adherens
    text
  • localized at the intercellular adherens junction
  • also secreted in breast and lung cancers
  • localized at cell-cell junctions of human keratinocytes (Brancati 2010)
  • basic FUNCTION
  • participating in the organization of epithelial and endothelial junctions
  • NECTIN1, NECTIN2, NECTIN3, NECTIN4 are involved in the formation of functioning adherence and tight junctions
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT4
  • PVRL1, nectin1 (ligand of nectin1 through V domain interaction)
  • cytoplasmic tails of the nectins bind the F-actin–binding protein afadin and support connections with the actin cytoskeleton similar to those observed in the cadherin and integrin systems
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EDCS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    transactivated in a majority of NSCLC (Takano 2009)
    tumoral        
    histological and serological tumor-associated marker for breast carcinoma (Fabre-Lafay 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • high level of expression is associated with poor prognosis in NSCLC (Takano 2009)
  • might play a significant role in lung carcinogenesis and should be a new candidate serum and tissue biomarker as well as a therapeutic target (Takano 2009)
  • marker of disease progression and levels correlating with the number of metastasis in breast carcinomas (Fabre-Lafay 2007)
  • ANIMAL & CELL MODELS