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FLASH GENE
Symbol NECTIN3 contributors: mct/shn/pgu - updated : 20-12-2013
HGNC name nectin cell adhesion molecule 3
HGNC id 17664
Location 3q13.13      Physical location : -
Synonym name
  • afadin-associated molecule
  • nectin 3
  • poliovirus receptor-related 3
  • Synonym symbol(s) PPR3, PRL3, NECT3, PRR3, CD113, PVRR3, CDw113, FLJ90624, nectin-3, DKFZp566B0846, PVRL3
    DNA
    TYPE functioning gene
    STRUCTURE 62.20 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D3S3695 - D3S4017 - PVRL3 - D3S4551 - D3S2496 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1650 - 549 - 2000 11024295
    EXPRESSION
    Rna function mRNA is localized along the heterotypic junctions between hair cells and supporting cells
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemplacenta  predominantly
     male systemtestis  predominantly Homo sapiens
    Visualeyelens    Mus musculus
     eyeanterior segment    Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    ReproductiveSertoli cell Homo sapiens
    Reproductivespermatid Homo sapiens
    cell lineage highly expressed in rabbit limbal epithelial side population (rLE-SP) cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta ,eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three extracellular Ig-like domains (V,C and C)
  • a consensus sequence A/EXYY for binding the PDZ domain
  • HOMOLOGY
    interspecies ortholog to Pvrl3, Mus musculus
    ortholog to pvrl3l, Danio rerio
    Homologene
    FAMILY nectin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text localized in epithelial cell-cell junctions in renal proximal tubules and in the amniotic membrane)
    basic FUNCTION
  • homophilic and heterophilic cell-cell adhesion activities
  • organizing adherens junctions cooperatively with the cadherin-catenin system in epithelial cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells
  • critical gene involved in a Nectin-mediated cell-cell adhesion mechanism in human ocular development
  • promote the formation of the checkerboard-like pattern of the auditory epithelia
  • involved in formation of the mechanical adhesive puncta adherentia junctions of synapses
  • NECTIN1, NECTIN2, NECTIN3, NECTIN4 are involved in the formation of functioning adherence and tight junctions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) translocated to 4, MLLT4
  • par-3 partitioning defective 3 homolog (C. elegans), PARD3
  • PVR
  • cytoplasmic tails of the nectins bind the F-actin–binding protein afadin and support connections with the actin cytoskeleton similar to those observed in the cadherin and integrin systems
  • molecular interaction between PVRL1 and PVRL33 is the strongest of all possible combinations of the three nectins, which is likely to be responsible for the checkerboard-like assembly of these cells
  • NECTIN3 trans-interacts with NECTIN2 to promote lymphocyte and monocyte extravasation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nectin-3(-/-) mice had defects in the later steps of sperm morphogenesis including distorted nuclei, abnormal distribution of mitochondria and in localization of nectin-2 at the Sertoli-spermatid junctions
  • Pvrl3 knockout mice as well as a spontaneous mouse mutant ari (anterior retinal inversion), that maps to the Pvrl3 locus, exhibit lens and other ocular defects involving the ciliary body
  • homozygous deletion of either Nectin2 or Nectin3 leads to male-specific infertility in mice