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FLASH GENE
Symbol NECTIN2 contributors: mct - updated : 20-12-2016
HGNC name nectin cell adhesion molecule 2
HGNC id 9707
Location 19q13.32      Physical location : -
Synonym name
  • poliovirus receptor-related 2
  • nectin-2
  • poliovirus receptor-related 2 (herpesvirus entry mediator B)
  • Synonym symbol(s) PRR2, HVEB, PVRR2, CD112, PVRL2,
    DNA
    TYPE functioning gene
    STRUCTURE 43.09 kb     6 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1370 - 449 ubiquitous 2013 24116228
    9 splicing 2869 - 539 ubiquitous 2013 24116228
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Reproductivemale systemtestis  highly Homo sapiens
     male systemprostate  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell Homo sapiens
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 2 Ig-like C2-type (immunoglobulin-like) domains
  • a Ig-like V-type (immunoglobulin-like) domain
  • extracellular domains are composed of an N-terminal variable-type Ig (IgV) domain, followed by two constant-type Ig (IgC) domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Mph gene
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • Herpes virus entry mediator B
  • Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells (Stanietsky 2009)
  • mediate cell–cell adhesion through homophilic and heterophilic interactions
  • NECTIN1, NECTIN2, NECTIN3, NECTIN4 are involved in the formation of functioning adherence and tight junctions
  • accumulation of a soluble form of NECTIN2 is required for exerting the resistance against herpes simplex virus type 2 (HSV-2) infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of TIGIT with PVR and NECTIN2 inhibits human NK cell cytotoxicity
  • cytoplasmic tails of the nectins bind the F-actin–binding protein afadin and support connections with the actin cytoskeleton similar to those observed in the cadherin and integrin systems
  • ZYX–NECTIN2 interaction plays a critical role in zyxin targeting to these sites
  • TIGIT is a novel inhibitory receptor, interacting with two ligands: PVR and NECTIN2 and to inhibit human NK-cell cytotoxicity
  • NECTIN3 trans-interacts with NECTIN2 to promote lymphocyte and monocyte extravasation
  • TIGIT, upon interaction with either of its two ligands, NECTIN2 or poliovirus receptor (PVR), inhibits activation of T and NK cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • putative susceptibility factor for Alzheimer's disease
  • nonsyndromic cleft lip with or without cleft palate
  • Variant & Polymorphism
  • G allele showed a significant elevated risk for nonsyndromic cleft lip with or without cleft palate
  • Candidate gene
    Marker
  • prognostic role of NECTIN2 in non-metastatic colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • homozygous deletion of either Nectin2 or Nectin3 leads to male-specific infertility in mice