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FLASH GENE
Symbol NECTIN1 contributors: mct - updated : 20-12-2013
HGNC name nectin cell adhesion molecule 1
HGNC id 9706
Corresponding disease
CLPED1 cleft lip/palate-ectodermal dysplasia syndrome
Location 11q23.3      Physical location : -
Synonym name
  • ectodermal dysplasia 4 (Margarita Island type)
  • herpesvirus entry mediator C
  • nectin 1
  • CD111 antigen
  • poliovirus receptor related
  • poliovirus receptor-related 1 (herpesvirus entry mediator C)
  • Synonym symbol(s) PRR1, SK12, HIGR, ED4, PRR, HVEC, PVRR, CD111, PVRR1, OFC7 HV1S, SK-12, CLPED1, PVRL1
    DNA
    TYPE virus associated
    STRUCTURE 67.73 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1549 - 458 - 1995 7721102
    6 - 1726 - 517 - 1995 7721102
    6 - 1451 - 352 - 1995 7721102
    EXPRESSION
    Rna function Nectin-1 mRNA was expressed in hair cells (PMIDS:
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one V-like extracellular Ig domain
  • a transmembrane region (TM)
  • an intracytoplasmic region
  • first and second Ig module in the extracellular region are necessary for the trans-interaction with PVRL3 and formation of cis-dimers, respectively
  • HOMOLOGY
    Homologene
    FAMILY
  • nectin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction,adherens
    text
  • synaptic localization for PVRL1 and MLLT4 are F-actin-dependent and the shedding of PVRL1 is a mechanism contributing to synaptic plasticity
  • basic FUNCTION
  • involved in cell adhesion
  • receptor for alpha-herpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells
  • immunoglobulin-like cell-cell adhesion molecule, which plays essential roles in the initial step of formation of adherens junctions and tight junction
  • plays a key role in the expression of loricrin in the epidermis
  • regulate tight junction formation, but however, may also participate in the regulation of desmosome assembly
  • cell adhesion molecule that, together with the intracellular binding partner afadin, mediate adhesion and signaling at a variety of intercellular junctions
  • promote the formation of the checkerboard-like pattern of the auditory epithelia
  • ectodomain shedding of PVRL1 regulates dendritic spine density and related synaptic functions
  • involved in formation of the mechanical adhesive puncta adherentia junctions of synapses
  • recruitment to the perisynaptic environment in the ventral hippocampus plays an important role in the formation of contextual fear memories
  • NECTIN1, NECTIN2, NECTIN3, NECTIN4 are involved in the formation of functioning adherence and tight junctions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of adherens junctions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with HSV glycoprotein
  • cytoplasmic tails of the nectins bind the F-actin–binding protein afadin and support connections with the actin cytoskeleton similar to those observed in the cadherin and integrin systems
  • molecular interaction between PVRL1 and PVRL33 is the strongest of all possible combinations of the three nectins, which is likely to be responsible for the checkerboard-like assembly of these cells
  • FGFR is a downstream signaling partner of PVRL1 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CLPED1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in squamous cell tumours
    Susceptibility for non syndromic cleft lip/palate
    Variant & Polymorphism other R210H and RH increasing the risk of non syndromic cleft lip/palate
    Candidate gene for non syndromic cleft lip/palate
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Pvrl1 exhibit defective enamel formation in their incisor teeth