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FLASH GENE
Symbol NECAB3 contributors: mct/npt - updated : 03-01-2009
HGNC name N-terminal EF-hand calcium binding protein 3
HGNC id 15851
Location 20q11.21      Physical location : 32.244.893 - 32.262.264
Synonym name
  • Nek2-Interacting Protein 1
  • X11L-binding protein 51
  • synaptotagmin interacting protein 2
  • amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein
  • neuronal calcium-binding protein NECAB3
  • synaptotagmin interacting protein STIP3
  • EF-hand calcium binding protein 3
  • Synonym symbol(s) NIP1, XB51, SYTIP2, EFCBP3, APBA2BP, dJ63M2.4, STIP3, dJ63M2.5
    DNA
    TYPE functioning gene
    STRUCTURE 17.34 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 1956 40.8 362 - Sugita (2002)
  • containing exons 1 and 2 (lacking intron 8 and an 3' UTR sequence)
  • using an upstream in-frame translational start codon in exon 1
  • identical C terminus than variant 2
  • 12 splicing 2058 - 395 - Sugita (2002)
  • lacking exons 1 and 2
  • containing intron 8 and an 3' UTR sequence
  • using an downstream in-frame translational start codon
  • identical C terminus than variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • EF-hand, calcium binding motif
  • HOMOLOGY
    interspecies homolog to murine Apba2bp
    homolog to Drosophila CG7187
    intraspecies homolog to NECAB1
    Homologene
    FAMILY
  • amyloid beta (A4) precursor protein-binding, family A
  • antibiotic biosynthesis monooxygenase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text localized around the nucleus
    basic FUNCTION
  • inhibiting the association of X11L with amyloid precursor protein through a non competitive mechanism
  • abolishing the suppression of beta-amyloid production by X11L
  • playing an important role in the regulatory system of amyloid precursor protein metabolism and beta amyloid generation (with X11L)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    amyloid precursor protein metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to the N terminal domain of the neuron-specific X11-like protein (X11L)
  • cell & other
    REGULATION
    Other phosphorylated by NEK2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS