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FLASH GENE

Symbol

NECAB2

contributors: mct/npt - updated : 03/01/2009

HGNC name	N-terminal EF-hand calcium binding protein 2
HGNC id	23746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q24.1      Physical location : 84.002.236 - 84.036.377
Synonym name	neuronal calcium binding 2
	EF hand calcium binding protein 2
	synaptotagmin-interacting protein 2
Synonym symbol(s)	EFCBP2, Stip-2

DNA

TYPE	anonymous DNA segment
STRUCTURE	34.14 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NECAB2 13 - 1636 43 386 - Sugita (2002)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus     Visual eye

cells

System Cell Pubmed Species Stage Rna symbol Nervous pyramidal cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

antibiotic biosynthesis monooxygenase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	regulatory calcium binding protein
	with ADORA2A, modulates the cell surface expression and function of the receptor (Canela 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with GRM5 (NECAB2 by its physical interaction with GRM5 modulates receptor function) (Canela 2009)
	binding partner for ADORA2A interacting with its C-terminal domain (interacts with NECAB2 in striatal neurones co-expressing the two proteins and the interaction is relevant for ADORA2A function)(Canela 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS