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FLASH GENE
Symbol NECAB2 contributors: mct/npt - updated : 03/01/2009
HGNC name N-terminal EF-hand calcium binding protein 2
HGNC id 23746
Location 16q24.1      Physical location : 84.002.236 - 84.036.377
Synonym name
  • neuronal calcium binding 2
  • EF hand calcium binding protein 2
  • synaptotagmin-interacting protein 2
  • Synonym symbol(s) EFCBP2, Stip-2
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 34.14 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1636 43 386 - Sugita (2002)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • antibiotic biosynthesis monooxygenase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulatory calcium binding protein
  • with ADORA2A, modulates the cell surface expression and function of the receptor (Canela 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRM5 (NECAB2 by its physical interaction with GRM5 modulates receptor function) (Canela 2009)
  • binding partner for ADORA2A interacting with its C-terminal domain (interacts with NECAB2 in striatal neurones co-expressing the two proteins and the interaction is relevant for ADORA2A function)(Canela 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS