Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NDUFS8 | contributors: - updated : 11-07-2007 |
HGNC name | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) |
HGNC id | 7715 |
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Corresponding disease |
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Location | 11q13 Physical location : 67.798.083 - 67.804.114 | ||
Synonym name | iron-sulfur protein 8,complex 1 of the respiratory chain | ||
Synonym symbol(s) | TYKY | ||
EC.number | 1.6.5.3 |
DNA |
TYPE | functioning gene |
STRUCTURE | 6.00 kb 7 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
Binding site | |
text structure | 3 Sp1 sites and one YY1 site were identified in this minimal promoter |
MAPPING | cloned | linked | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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secondary structure | forty different subunits (TYKY subunit) |
mono polymer | octamer |
HOMOLOGY |
interspecies | homolog to C.elegans t20h4.5 |
Homologene |
FAMILY | complex 1,23kDa subunit family |
CATEGORY | enzyme , transport carrier |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria,inner |
basic FUNCTION | may donate electrons to ubiquinone |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS) |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | NDUFS8 |
related resource | MITOP database |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |