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FLASH GENE
Symbol NDUFB7 contributors: mct - updated : 22-10-2011
HGNC name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
HGNC id 7702
Location 19p13.12      Physical location : 14.676.891 - 14.682.886
Synonym name NADH-ubiquinone oxidoreductase B18 subunit
Synonym symbol(s) B18, CI-B18, MGC2480
EC.number 1.6.5.3/1.6.99.3
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LPHN1 19p13.2 latrophilin 1 CD97 19p13.2-p13.12 CD97 antigen DDX39 19p13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 PRKCL1 19p13.1-p12 protein kinase C-like 1 PTGER1 19p13.1 prostaglandin E receptor 1 (subtype EP1), 42kDa RGS19IP1 19p13.2-p13.1 regulator of G-protein signalling 19 interacting protein 1 DNAJB1 19p13.2 DnaJ (Hsp40) homolog, subfmaily B, member 1 GPSN2 19p13.12 glycoprotein, synaptic 2 NDUFB7 19p13.12-p13.11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa LOC388512 19 similar to Asialoglycoprotein receptor 2 (Hepatic lectin H2) (ASGP-R) (ASGPR) EMR3 19p13.1 egf-like module containing, mucin-like, hormone receptor-like 3 ZNF333 19p13 zinc finger protein 333 EMR2 19p13.1 egf-like module containing, mucin-like, hormone receptor-like sequence 2 OR7C1 19p13.1 olfactory receptor, family 7, subfamily C, member 1 OR7A5 19p13.1 olfactory receptor, family 7, subfamily A, member 5 pseudogene LOC390892 19 similar to Olfactory receptor 7A10 (OST027) LOC390893 19 similar to Olfactory receptor 7A10 (OST027) LOC390894 19 similar to Olfactory receptor 7A2 OR7A17 19p13.13 olfactory receptor, family 7, subfamily A, member 17 OR7A18P 19p13.13 olfactory receptor, family 7, subfamily A, member 18 pseudogene LOC390895 19 similar to olfactory receptor, family 7, subfamily A, member 17 OR7A14P 19p13.1 olfactory receptor, family 7, subfamily A, member 14 pseudogene OR7A11P 19p13.1 olfactory receptor, family 7, subfamily A, member 11 pseudogene OR7A15P 19p13.1 olfactory receptor, family 7, subfamily A, member 15 pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 573 - 137 - 2011 21310150
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine residues
  • only one Cx9C domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    text with NDUFA8, located at the intermembrane surface of complex I, and stabilize the membrane domain of complex I
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component beta 7, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDUFA8 forms intramolecular disulfide bridges and, together with NDUFB7, is localized in the mitochondrial inter membrane space
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS