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FLASH GENE
Symbol NDUFB7 contributors: mct - updated : 22-10-2011
HGNC name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
HGNC id 7702
Location 19p13.12      Physical location : 14.676.891 - 14.682.886
Synonym name NADH-ubiquinone oxidoreductase B18 subunit
Synonym symbol(s) B18, CI-B18, MGC2480
EC.number 1.6.5.3/1.6.99.3
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 573 - 137 - 2011 21310150
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine residues
  • only one Cx9C domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    text with NDUFA8, located at the intermembrane surface of complex I, and stabilize the membrane domain of complex I
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component beta 7, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDUFA8 forms intramolecular disulfide bridges and, together with NDUFB7, is localized in the mitochondrial inter membrane space
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS