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FLASH GENE
Symbol NDUFB5 contributors: npt/mct - updated : 11-02-2010
HGNC name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
HGNC id 7700
Location 3q26.33      Physical location : 179.322.574 - 179.342.287
Synonym name
  • NADH-ubiquinone oxidoreductase SGDH subunit
  • complex I-SGDH
  • Synonym symbol(s) SGDH, CI-SGDH, MGC12314, DKFZp686N02262, FLJ30597, MGC111204
    EC.number 1.6.5.3, 1.6.99.3
    DNA
    TYPE functioning gene
    STRUCTURE 19.71 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KCNMB2 3q26.3-q27.1 potassium large conductance calcium-activated channel, subfamily M, beta member 2 WIG1 3q26.3-q27 potassium large conductance calcium-activated channel, subfamily M, beta member 2 PIK3CA 3q26.3 phosphoinositide-3-kinase, catalytic, alpha polypeptide KCNMB3 3q26.3-q27.1 potassium large conductance calcium-activated channel, subfamily M beta member 3 ANC_2H01 3q27.1 zinc finger protein ANC_2H01 MFN1 3q27.1 mitofusin 1 GNB4 21q22.3 guanine nucleotide binding protein (G protein), beta polypeptide 4 BAF53A 3q27.1 guanine nucleotide binding protein (G protein), beta polypeptide 4 MRPL47 3q27.1 mitochondrial ribosomal protein L47 NDUFB5 3q27.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa USP13 3q26.2-q26.3 ubiquitin specific protease 13 (isopeptidase T-3) PEX5R 3q27.1 Pex5p-related protein LOC391593 3 similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) LOC131054 3q27.2 similar to RalA binding protein 1 (RalBP1) (Ral interacting protein 1) (76-kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) TTC14 3q27.2 tetratricopeptide repeat domain 14 DKFZp434A128 3q27.2 hypothetical protein DKFZp434A128 LOC389178 3 similar to RING finger protein 13 LOC391594 3 similar to KIAA1552 protein LOC391595 3 similar to 60S ribosomal protein L32 FXR1 3q28 fragile X mental retardation, autosomal homolog 1 LOC131118 LOC391596 3 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1088 - 189 - Loeffen (1998)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • mitochondria transit peptide
  • NADH-ubiquinone oxidoreductase SGDH subunit
  • mono polymer heteromer , complex
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Ndufb5
    homolog to C.elegans Y17D7A.1
    Homologene
    FAMILY
  • complex I NDUFB5 subunit family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • transfer of electrons from NADH to the respiratory chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the forty-one subunits of the complex I of respiratory chain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS