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FLASH GENE
Symbol NDUFA8 contributors: mct - updated : 22-08-2011
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
HGNC id 7692
Location 9q33.2      Physical location : 124.906.339 - 124.922.098
Synonym name NADH:ubiquinone oxidoreductase PGIV subunit
Synonym symbol(s) PGIV, CI-19KD, CI-PGIV, MGC793
EC.number 1.6.99.3
DNA
TYPE functioning gene
STRUCTURE 15.76 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
CEP1 9q33 centrosomal protein 1 RAB14 9q32-q34.11 RAB14, member RAS oncogene family LOC392388 9 similar to vacuolar H+-ATPase B subunit GSN 9q33.3 gelsolin (amyloidosis, Finnish type) MOST2 9q34.11 MOST2 protein STOM 9q34.1 stomatin a1/3GTP 9q34.11 alpha-1,3-galactosyltransferase pseudogene DAB2IP 9q33.1-q33.3 DAB2 interacting protein LOC158135 9q34.11 similar to H23L24.3.p NDUFA8 9q32.4-q34.41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa FLJ46909 9q34.11 FLJ46909 protein LHX6 9q34.11 LIM homeobox 6 MGC2734 MRRF 9q33-q34.1 mitochondrial ribosome recycling factor PTGS1 9q32-q33.3 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) LOC347168 9q34.11 similar to Olfactory receptor 1J1 OR1J5 9q34.11 olfactory receptor, family 1, subfamily J, member 5 OR1J4 9q34.2 olfactory receptor, family 1, subfamily J, member 4 LOC138883 9q34.11 similar to Olfactory receptor 1N3 LOC138882 9q34.11 similar to Olfactory receptor 1N2 LOC138881 9q34.11 similar to Olfactory receptor 1L8 LOC392389 9 similar to G protein-coupled receptor homolog clone H8 LOC158131 9q34.11 similar to Olfactory receptor 1Q1 (Olfactory receptor TPCR106) (Olfactory receptor 9-A) (OR9-A) (OST226) LOC347169 9q34.11 similar to Olfactory receptor 1B1 (Olfactory receptor 9-B) (OR9-B) LOC158130 9q34.11 similar to tousled-like kinase 1; serine threonine protein kinase LOC254973 9q34.11 similar to Olfactory receptor 1L4 (Olfactory receptor 9-E) (OR9-E) (OST046) LOC392390 9 similar to Olfactory receptor 1L6 LOC389789 9 similar to hypothetical protein LOC348235 LOC392391 9 similar to Olfactory receptor 5C1 (Olfactory receptor 9-F) (OR9-F) LOC392392 9 similar to Olfactory receptor 1K1 PDCL 9q12-q13 phosducin-like MNAB 9q34 phosducin-like ZNF482 9q34.11 zinc finger protein 482 ZNF481 9 zinc finger protein 481 GAPCENA 9q33.1-q33.3 zinc finger protein 481 GPR21 9q33 G protein-coupled receptor 21 C9orf45 9q34.11 chromosome 9 open reading frame 45 STRBP 9q34.11 spermatid perinuclear RNA binding protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 859 - 172 - 2011 21310150
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
 parathyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a motif of eight cysteine residues
  • two twin Cx9C domains
  • a hydrophobic motif at the N terminus, suggesting that the protein is incorporated in the mitochondrial inner membrane
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    text with NDUFB, located at the intermembrane surface of complex I, and stabilize the membrane domain of complex I
    basic FUNCTION may play an important role in mitochondrial function
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component alpha 8, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein NDUFA8 forms intramolecular disulfide bridges and, together with NDUFB7, is localized in the mitochondrial inter membrane space
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS