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FLASH GENE
Symbol NDUFA5 contributors: - updated : 17-10-2007
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
HGNC id 7688
Location 7q31.33      Physical location : 123.181.083 - 123.197.958
Synonym name complex I-13KD-B
Synonym symbol(s) UOR4, B13, CI-13KD-B, NUFM, UQOR13
EC.number 1.6.5.3
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal part with a putative beta sheet rich in hydrophobic AAs that may serve as mitochondrial import signal
  • C-terminal half of the protein having high potential to adopt a coiled-coil form
  • HOMOLOGY
    interspecies homolog to bovine
    homolog to rattus subunit B13
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION NADH ubiquinone oxidoreductase (Q reductase)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component alpha 5,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS