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FLASH GENE

Symbol

NDUFA13

contributors: mct - updated : 18-12-2010

HGNC name	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
HGNC id	17194

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.11      Physical location : 19.627.018 - 19.639.013
Synonym name	gene associated with retinoid-IFN-induced mortality 19
	cell death-regulatory protein GRIM19
	retinoid-IFN-induced mortality 19
	complex I B16.6 subunit
	NADH-ubiquinone oxidoreductase B16.6 subunit
Synonym symbol(s)	B16.6, CDA016, CGI-39, GRIM-19, GRIM19, FLJ58045, FLJ59191

DNA

TYPE	functioning gene
STRUCTURE	12.00 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015965 5 - 557 NP_057049 16 144 - 2000 10924506

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine neuroendocrine pituitary     highly   parathyroid       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	numerous fetal tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mitochondrial localization sequences at the N-terminus

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus,nucleoplasm
text	primarily a nuclear protein

basic FUNCTION	death-inductive role in the IFN retinoid regulated pathway
	involved in transfer of electrons from NADH to the respiratory chain
	required for electron transfer activity of complex I, and essential for maintenance of mitochondrial membrane potential
	inhibits SRC-induced oncogenic transformation and metastatic behavior of cells
	promotes the inhibitory effect of CDKN2A on CDK4
	regulatory gene necessary for interferon-beta and retinoic acid-induced cell death

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

functional component of mitochondrial complex I and essential for early embryonic development

INTERACTION

DNA

RNA

small molecule

protein	NDUFA13/CDKN2A synergistically suppressed cell cycle progression via inhibiting E2F1-driven gene expression (N- terminus of NDUFA13 and the fourth ankyrin repeat of CDKN2A are crucial for their interaction)
	interact physically with STAT3 and inhibit STAT3-dependent signal transduction

cell & other

REGULATION

induced by

interferon beta combined with all-trans-retinoic acid

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in primary renal cell carcinomas (RCCs) and in some urinogenital tumors

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	overexpression in cancer cells suppresses STAT3-mediated signal transduction and cancer growth, having potential as a novel anticancer therapy in STAT3c cancer
	suppressed the expression of tumor invasion- and angiogenesis-associated factors to limit tumor growth in cervical cancer

ANIMAL & CELL MODELS