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FLASH GENE
Symbol NDUFA11 contributors: mct/npt - updated : 24-03-2001
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
HGNC id 20371
Corresponding disease
NDUFA11D NDUFA11 deficiency
Location 19p13.3      Physical location : 5.891.286 - 5.904.024
Synonym name
  • complex I-B14.7
  • NADH-ubiquinone oxidoreductase subunit B14.7
    • Synonym symbol(s) B14.7, CI-B14.7
    EC.number 1.6.5.3
    DNA
    TYPE functioning gene
    STRUCTURE 9.34 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 819 14.7 141 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • complex I NDUFA11 subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may be involved in protein translocation across the inner membrane (Carroll 2002)
  • characteristics of TIMMDC1, of another assembly factor, TMEM126B, and of NDUFA11 suggest that they all participate in constructing the membrane arm of complex I
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFA11D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS